A method for producing tricyclo[5.2.1.0.sup.2,6]decane-2-carboxylate according to the present invention is a method for producing tricyclo[5.2.1.0.sup.2,6]decane-2-carboxylate, containing reacting tricyclo[5.2.1.0.sup.2,6]deca-3-ene in a dilute solution containing the tricyclo[5.2.1.0.sup.2,6]deca-3-ene with carbon monoxide in the presence of an acid catalyst, followed by reaction with an alcohol, wherein the dilute solution contains 100 parts by mass or more of a tricyclo[5.2.1.0.sup.2,6]decane isomer mixture based on 100 parts by mass of the tricyclo[5.2.1.0.sup.2,6]deca-3-ene, the tricyclo[5.2.1.0.sup.2,6]decane isomer mixture contains endo-tricyclo[5.2.1.0.sup.2,6]decane (Endo form of TCD) and exo-tricyclo[5.2.1.0.sup.2,6]decane (Exo form of TCD), and a constituent ratio thereof (Endo form of TCD/Exo form of TCD) is greater than 1.0.

A method for producing tricyclo[5.2.1.0.sup.2,6]decane-2-carboxylate according to the present invention is a method for producing tricyclo[5.2.1.0.sup.2,6]decane-2-carboxylate, containing reacting tricyclo[5.2.1.0.sup.2,6]deca-3-ene in a dilute solution containing the tricyclo[5.2.1.0.sup.2,6]deca-3-ene with carbon monoxide in the presence of an acid catalyst, followed by reaction with an alcohol, wherein the dilute solution contains 100 parts by mass or more of a tricyclo[5.2.1.0.sup.2,6]decane isomer mixture based on 100 parts by mass of the tricyclo[5.2.1.0.sup.2,6]deca-3-ene, the tricyclo[5.2.1.0.sup.2,6]decane isomer mixture contains endo-tricyclo[5.2.1.0.sup.2,6]decane (Endo form of TCD) and exo-tricyclo[5.2.1.0.sup.2,6]decane (Exo form of TCD), and a constituent ratio thereof (Endo form of TCD/Exo form of TCD) is greater than 1.0.

Ru-catalysed domino hydroformylation/hydrogenation/esterification using phosphine ligands.

Ru-catalysed domino hydroformylation/hydrogenation/esterification using phosphine ligands.

Ru-catalysed domino hydroformylation/hydrogenation/esterification using phosphine ligands.

Improved methods and intermediates thereof for preparing carbamoyloxy methyl triazole cyclohexyl acid compounds are described. These compounds are useful as LPA antagonists. Formula (I).

##STR00001##

Improved methods and intermediates thereof for preparing carbamoyloxy methyl triazole cyclohexyl acid compounds are described. These compounds are useful as LPA antagonists. Formula (I).

##STR00001##

An object of the present invention is to provide a novel method for producing an α-fluoroacrylic acid ester compound. ##STR00001##
This problem is solved by a method for producing a compound represented by formula (1), wherein R.sup.1 and R.sup.2 are identical or different, and each represents an alkyl group or the like; and R.sup.3 is an alkyl group or the like, the method comprising step A of reacting a compound represented by formula (2) with R.sup.3—OH (3) and carbon monoxide in the presence of palladium, a double bond-containing compound (α), a diphosphine compound (β), and a base, to obtain the compound represented by formula (1) above.

An object of the present invention is to provide a novel method for producing an α-fluoroacrylic acid ester compound. ##STR00001##
This problem is solved by a method for producing a compound represented by formula (1), wherein R.sup.1 and R.sup.2 are identical or different, and each represents an alkyl group or the like; and R.sup.3 is an alkyl group or the like, the method comprising step A of reacting a compound represented by formula (2) with R.sup.3—OH (3) and carbon monoxide in the presence of palladium, a double bond-containing compound (α), a diphosphine compound (β), and a base, to obtain the compound represented by formula (1) above.

An object of the present invention is to provide a novel method for producing an α-fluoroacrylic acid ester compound. ##STR00001##
This problem is solved by a method for producing a compound represented by formula (1), wherein R.sup.1 and R.sup.2 are identical or different, and each represents an alkyl group or the like; and R.sup.3 is an alkyl group or the like, the method comprising step A of reacting a compound represented by formula (2) with R.sup.3—OH (3) and carbon monoxide in the presence of palladium, a double bond-containing compound (α), a diphosphine compound (β), and a base, to obtain the compound represented by formula (1) above.