Patent classifications
C07C68/06
Ibuprofen ester derivative and emulsion preparation thereof
The application related to an ibuprofen ester derivative and an emulsion preparation thereof. A carboxyl group of racemic ibuprofen or S-ibuprofen is derivatized so that Compound N9 and a dextrorotatory enantiomer N9(S) thereof are obtained and further prepared into an emulsion preparation, which overcomes the problems of safety and compliance of patients existing in clinical application of existing ibuprofen/dexibuprofen injections and achieves the purposes of reducing vascular irritation, increasing clinical use approaches, and improving the stability of preparations in clinical applications.
Method of preparing heterogeneous linear carbonate using catalyst having excellent solubility
The present invention relates to a method of preparing a heterogeneous linear carbonate, the method including performing a transesterification reaction of dimethyl carbonate (DMC) and ethanol (EtOH) in the presence of a catalyst, wherein the catalyst is one or more selected from the group consisting of lithium methoxide (LME), lithium ethoxide (LEE), sodium methoxide (SME), sodium hydroxide (NaOH), and a mixture thereof, and the catalyst is input in a state of being dissolved in a sulfoxide-based solvent.
Method of preparing heterogeneous linear carbonate using catalyst having excellent solubility
The present invention relates to a method of preparing a heterogeneous linear carbonate, the method including performing a transesterification reaction of dimethyl carbonate (DMC) and ethanol (EtOH) in the presence of a catalyst, wherein the catalyst is one or more selected from the group consisting of lithium methoxide (LME), lithium ethoxide (LEE), sodium methoxide (SME), sodium hydroxide (NaOH), and a mixture thereof, and the catalyst is input in a state of being dissolved in a sulfoxide-based solvent.
Method of preparing heterogeneous linear carbonate using amine-based compound catalyst
The present invention is directed to providing a method of preparing a heterogeneous linear carbonate, including: performing a transesterification reaction of dimethyl carbonate (DMC) and ethanol (EtOH) in the presence of a catalyst, wherein the catalyst is an amine-based compound having a boiling point of 150 C. or more.
Method of preparing heterogeneous linear carbonate using amine-based compound catalyst
The present invention is directed to providing a method of preparing a heterogeneous linear carbonate, including: performing a transesterification reaction of dimethyl carbonate (DMC) and ethanol (EtOH) in the presence of a catalyst, wherein the catalyst is an amine-based compound having a boiling point of 150 C. or more.