The present invention relates to a novel and improved process for preparing (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoic acid of the formula (I), to the compound of the formula (I) in crystalline form and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular, cardiopulmonary and cardiorenal disorders.

The present invention relates to a novel and improved process for preparing (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoic acid of the formula (I), to the compound of the formula (I) in crystalline form and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular, cardiopulmonary and cardiorenal disorders.

The present invention aims to provide a novel compound useful as a perfume material and a perfume composition containing the same, as well as a perfumed product.

The present invention provides a compound represented by the following general formula:

##STR00001##

wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently a hydrogen atom or a methyl group, Y.sup.1 and Y.sup.2 are each independently —O—CO—Z, —O—CO—O—Z or the like, Y.sup.3 is —O—CO—Z.sup.3, where Z and Z.sup.3 are each a linear or branched alkyl group containing 1 to 5 carbon atoms or a cycloalkyl group containing 3 to 5 carbon atoms or the like, and n is 2 or 3, and a perfume composition containing the same, as well as a product perfumed with the composition.

The present invention aims to provide a novel compound useful as a perfume material and a perfume composition containing the same, as well as a perfumed product.

The present invention provides a compound represented by the following general formula:

##STR00001##

wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently a hydrogen atom or a methyl group, Y.sup.1 and Y.sup.2 are each independently —O—CO—Z, —O—CO—O—Z or the like, Y.sup.3 is —O—CO—Z.sup.3, where Z and Z.sup.3 are each a linear or branched alkyl group containing 1 to 5 carbon atoms or a cycloalkyl group containing 3 to 5 carbon atoms or the like, and n is 2 or 3, and a perfume composition containing the same, as well as a product perfumed with the composition.

Process for the alkoxycarbonylation of trivinylcyclohexane.

The invention relates to triesters of cyclohexanetripropionic acid, preparation thereof and use thereof as plasticizers for polymers.

The invention relates to triesters of cyclohexanetripropionic acid, preparation thereof and use thereof as plasticizers for polymers.

The present invention relates to a derivative of 13-oxidized ingenol, use thereof in the prevention and/or treatment of a disease associated with proliferation or tumor in a subject, or a cosmetic indication, and use thereof in the prevention and/or treatment of a disease responsive to neutrophil oxidative burst, a disease responsive to a release of IL-8 by keratinocyte, or a disease responsive to induction of necrosis.

The present invention relates to a derivative of 13-oxidized ingenol, use thereof in the prevention and/or treatment of a disease associated with proliferation or tumor in a subject, or a cosmetic indication, and use thereof in the prevention and/or treatment of a disease responsive to neutrophil oxidative burst, a disease responsive to a release of IL-8 by keratinocyte, or a disease responsive to induction of necrosis.

The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.

##STR00001##