Disclosed is a method for crystallizing molecules having a molecular weight equal to or lower than about 500 Dalton in a gravity below about 0.01 g to about 0.000001 g as well as to crystalline molecules having a molecular weight equal to, or lower than, about 500 Dalton, prepared under microgravity conditions.

Disclosed is a method for crystallizing molecules having a molecular weight equal to or lower than about 500 Dalton in a gravity below about 0.01 g to about 0.000001 g as well as to crystalline molecules having a molecular weight equal to, or lower than, about 500 Dalton, prepared under microgravity conditions.

Process for manufacturing ethyleneamine compounds selected from the group of ethyleneamines and hydroxyethylethyleneamines wherein the process comprises two reaction sequences.

Process for manufacturing ethyleneamine compounds selected from the group of ethyleneamines and hydroxyethylethyleneamines wherein the process comprises two reaction sequences.

Provided are a device and a method for purifying an organic amine solution. The device includes an ion exchange bed having an upper feeding port, through which the ion exchange bed is communicated with an inert gas cylinder, a fifth liquid storage tank and a second liquid adding pump; a lower feeding port, through which the ion exchange bed is communicated with a first liquid adding pump; a lower discharging port, through which the ion exchange bed is communicated with a second liquid storage tank, a third liquid storage tank and a fourth liquid storage tank; and an upper discharging port, through which the ion exchange bed is communicated with the fourth liquid storage tank.

Provided are a device and a method for purifying an organic amine solution. The device includes an ion exchange bed having an upper feeding port, through which the ion exchange bed is communicated with an inert gas cylinder, a fifth liquid storage tank and a second liquid adding pump; a lower feeding port, through which the ion exchange bed is communicated with a first liquid adding pump; a lower discharging port, through which the ion exchange bed is communicated with a second liquid storage tank, a third liquid storage tank and a fourth liquid storage tank; and an upper discharging port, through which the ion exchange bed is communicated with the fourth liquid storage tank.

The present disclosure relates to methods for the production of the isomerically pure or isomerically enriched cis-clomiphene and salts thereof.

The present disclosure relates to methods for the production of the isomerically pure or isomerically enriched cis-clomiphene and salts thereof.

The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.

The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.