Synthetic methods for the preparation of ligands and metal-ligand complexes are disclosed.

Synthetic methods for the preparation of ligands and metal-ligand complexes are disclosed.

Provided are vitamin D.sub.3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

Provided are vitamin D.sub.3 derivatives of formula (I), pharmaceutical compositions thereof, and pharmaceutical or medical uses thereof for treating metabolic disease, a liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.

Compounds of Formula I or II, methods of preparation and of use thereof. Formula I has a core aromatic group with substituents as follows: Formula (I) wherein G.sub.1 is (CH.sub.2).sub.nC(R.sub.1)(R.sub.2)OH, (CH.sub.2).sub.n; CHO, (CH.sub.2).sub.nC(O)NR.sub.1R.sub.2, (CH.sub.2).sub.nCH (R.sub.1)NR.sub.1R.sub.2, (CH.sub.2).sub.nC(O)OR.sub.3, (CH.sub.2).sub.nCH(R.sub.1)OR.sub.3, or (CH.sub.2).sub.nC(O)R.sub.3; G.sub.2 and G.sub.4 are independently H, OH, F, or Cl, where G.sub.2 can also be NH.sub.2; G.sub.3 and G.sub.5 are independently (H, F, Cl, OH, (CH.sub.2).sub.n-optionally substituted heterocycle, (CH.sub.2).sub.n-optionally substituted phenyl, (CH.sub.2).sub.nC.sub.3H.sub.5, optionally substituted C.sub.1-C.sub.6 alkyl, optionally substituted C.sub.2-C.sub.6 alkenyl, C(O)R.sub.3, or CH(OH)R.sub.3; and G.sub.6 is H, F, Cl, OH, (CH.sub.2).sub.n-optionally substituted heterocycle, (CH.sub.2).sub.n-optionally substituted phenyl, or (CH.sub.2).sub.nCOOH, wherein ?n is an integer selected from 0 to 5, ?R.sub.1 and R.sub.2 are independently selected from H and optionally substituted C.sub.1-C.sub.6 alkyl group, and ?R.sub.3 is an optionally substituted C.sub.1-C.sub.6 alkyl group or when present on G.sub.1 forms a lactone with the core aromatic group, or a pharmaceutically acceptable salt thereof.

##STR00001##

Compounds of Formula I or II, methods of preparation and of use thereof. Formula I has a core aromatic group with substituents as follows: Formula (I) wherein G.sub.1 is (CH.sub.2).sub.nC(R.sub.1)(R.sub.2)OH, (CH.sub.2).sub.n; CHO, (CH.sub.2).sub.nC(O)NR.sub.1R.sub.2, (CH.sub.2).sub.nCH (R.sub.1)NR.sub.1R.sub.2, (CH.sub.2).sub.nC(O)OR.sub.3, (CH.sub.2).sub.nCH(R.sub.1)OR.sub.3, or (CH.sub.2).sub.nC(O)R.sub.3; G.sub.2 and G.sub.4 are independently H, OH, F, or Cl, where G.sub.2 can also be NH.sub.2; G.sub.3 and G.sub.5 are independently (H, F, Cl, OH, (CH.sub.2).sub.n-optionally substituted heterocycle, (CH.sub.2).sub.n-optionally substituted phenyl, (CH.sub.2).sub.nC.sub.3H.sub.5, optionally substituted C.sub.1-C.sub.6 alkyl, optionally substituted C.sub.2-C.sub.6 alkenyl, C(O)R.sub.3, or CH(OH)R.sub.3; and G.sub.6 is H, F, Cl, OH, (CH.sub.2).sub.n-optionally substituted heterocycle, (CH.sub.2).sub.n-optionally substituted phenyl, or (CH.sub.2).sub.nCOOH, wherein ?n is an integer selected from 0 to 5, ?R.sub.1 and R.sub.2 are independently selected from H and optionally substituted C.sub.1-C.sub.6 alkyl group, and ?R.sub.3 is an optionally substituted C.sub.1-C.sub.6 alkyl group or when present on G.sub.1 forms a lactone with the core aromatic group, or a pharmaceutically acceptable salt thereof.

##STR00001##

Synthetic methods for the preparation of ligands and metal-ligand complexes are disclosed.

Synthetic methods for the preparation of ligands and metal-ligand complexes are disclosed.

The invention relates to compounds, compositions and methods for activating, reactivating, reversing or preventing the deactivation of cholinesterases, such as acetylcholinesterase and butyrylcholinesterase.

The invention relates to compounds, compositions and methods for activating, reactivating, reversing or preventing the deactivation of cholinesterases, such as acetylcholinesterase and butyrylcholinesterase.