A new composition of matter has the molecular structure [I]: Formula (I) wherein R.sub.1 is an alkyl, cycloalkyl, aralkyl group having 1 to 10 carbon atoms; R.sub.2 is selected from the group consisting of an aliphatic C.sub.1-C.sub.10 group, an unsaturated C.sub.1-C.sub.10 chain, C.sub.4-C.sub.9 group with a cyclic portion and C.sub.4-C.sub.10 group with an aromatic portion, and combinations thereof; R.sub.3 is selected from the group consisting of hydrogen, an aliphatic C.sub.1-C.sub.10 group, an unsaturated C.sub.2-C.sub.10 chain, a C.sub.4-C.sub.10 group with a cyclic portion, C.sub.4-C.sub.10 group with an aromatic portion, and combinations thereof; and R.sub.4 is a terminal functional group selected from the group consisting of amide [CONH.sub.2], acid [COOH], amine [CH.sub.2NH.sub.2], guanamine [(C.sub.3N.sub.3)(NH.sub.2).sub.2], organic heterocyclic [CHN.sub.4], and combinations thereof; and wherein said composition of matter of the molecular structure [I] excludes 2-[(3-amino-1-ethylpropyl)amino]ethanol.

##STR00001##

A new composition of matter has the molecular structure [I]: Formula (I) wherein R.sub.1 is an alkyl, cycloalkyl, aralkyl group having 1 to 10 carbon atoms; R.sub.2 is selected from the group consisting of an aliphatic C.sub.1-C.sub.10 group, an unsaturated C.sub.1-C.sub.10 chain, C.sub.4-C.sub.9 group with a cyclic portion and C.sub.4-C.sub.10 group with an aromatic portion, and combinations thereof; R.sub.3 is selected from the group consisting of hydrogen, an aliphatic C.sub.1-C.sub.10 group, an unsaturated C.sub.2-C.sub.10 chain, a C.sub.4-C.sub.10 group with a cyclic portion, C.sub.4-C.sub.10 group with an aromatic portion, and combinations thereof; and R.sub.4 is a terminal functional group selected from the group consisting of amide [CONH.sub.2], acid [COOH], amine [CH.sub.2NH.sub.2], guanamine [(C.sub.3N.sub.3)(NH.sub.2).sub.2], organic heterocyclic [CHN.sub.4], and combinations thereof; and wherein said composition of matter of the molecular structure [I] excludes 2-[(3-amino-1-ethylpropyl)amino]ethanol.

##STR00001##

The present disclosures are directed to processes for synthesizing(S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide (nirogacestat).

The present disclosures are directed to processes for synthesizing(S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide (nirogacestat).