The present invention provides a method of industrially and safely producing lacosamide high in diastereomeric excess at a high yield and a low cost. Adopting a particular isomerization-crystallization condition makes it possible to a method of industrially and safely producing lacosamide high in diastereomeric excess at a high yield and a low cost. Additionally, an intermediate efficacious for producing lacosamide is provided.

The present invention provides a method of industrially and safely producing lacosamide high in diastereomeric excess at a high yield and a low cost. Adopting a particular isomerization-crystallization condition makes it possible to a method of industrially and safely producing lacosamide high in diastereomeric excess at a high yield and a low cost. Additionally, an intermediate efficacious for producing lacosamide is provided.

Provided herein are integrated methods and systems for the production of acrylamide and acrylonitrile compounds and other compounds from at least beta-lactones and/or beta-hydroxy amides.

Provided herein are integrated methods and systems for the production of acrylamide and acrylonitrile compounds and other compounds from at least beta-lactones and/or beta-hydroxy amides.

##STR00001##

Disclosed is a method for preparing compound Formula S-1, comprising resolving compound Formula rac-2 with a compound of Formula 3 wherein R.sup.1.Math.R.sup.4, m and n are as defined in the disclosure.

##STR00001##

Disclosed is a method for preparing compound Formula S-1, comprising resolving compound Formula rac-2 with a compound of Formula 3 wherein R.sup.1.Math.R.sup.4, m and n are as defined in the disclosure.

##STR00001##

Disclosed is a method for preparing compound Formula S-1, comprising resolving compound Formula rac-2 with a compound of Formula 3 wherein R.sup.1.Math.R.sup.4, m and n are as defined in the disclosure.

A process for preparing 1,1,3-trimethylindan-4-amine of formula (I), or a salt thereof, enriched in one of its two enantiomers, in particular the (R) enantiomer,

##STR00001##

including chirally separating an optionally substituted 2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline of formula (III)

##STR00002##

A process may prepare one or more optically active amides of formula (II)

##STR00003##

starting from compounds of formula (I).

A process for preparing 1,1,3-trimethylindan-4-amine of formula (I), or a salt thereof, enriched in one of its two enantiomers, in particular the (R) enantiomer,

##STR00001##

including chirally separating an optionally substituted 2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline of formula (III)

##STR00002##

A process may prepare one or more optically active amides of formula (II)

##STR00003##

starting from compounds of formula (I).

A process for preparing 1,1,3-trimethylindan-4-amine of formula (I), or a salt thereof, enriched in one of its two enantiomers, in particular the (R) enantiomer,

##STR00001##

including chirally separating an optionally substituted 2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline of formula (III)

##STR00002##

A process may prepare one or more optically active amides of formula (II)

##STR00003##

starting from compounds of formula (I).