Acrylamide photoinitiators are provided, in which a photoinitiator moiety and an acrylamide are incorporated into the photoinitiator structure.

Acrylamide photoinitiators are provided, in which a photoinitiator moiety and an acrylamide are incorporated into the photoinitiator structure.

Acrylamide photoinitiators are provided, in which a photoinitiator moiety and an acrylamide are incorporated into the photoinitiator structure.

There are provided a surface-modified nanodiamond exhibiting easy dispersibility in an organic solvent, an organic solvent dispersion thereof, and a method for producing the surface-modified nanodiamond. The surface-modified nanodiamond according to the present invention includes a nanodiamond, and a group bound to a particulate surface of the nanodiamond and represented by formula (1):
NHCOR (1) R is an organic group having a carbon atom at a binding site with a neighboring carbonyl carbon atom indicated in the formula; and the left end, in the formula, of the group serves to form bonding to the nanodiamond. The nanodiamond is preferably a detonation nanodiamond or a high-temperature high-pressure nanodiamond.

There are provided a surface-modified nanodiamond exhibiting easy dispersibility in an organic solvent, an organic solvent dispersion thereof, and a method for producing the surface-modified nanodiamond. The surface-modified nanodiamond according to the present invention includes a nanodiamond, and a group bound to a particulate surface of the nanodiamond and represented by formula (1):
NHCOR (1) R is an organic group having a carbon atom at a binding site with a neighboring carbonyl carbon atom indicated in the formula; and the left end, in the formula, of the group serves to form bonding to the nanodiamond. The nanodiamond is preferably a detonation nanodiamond or a high-temperature high-pressure nanodiamond.

The present invention relates to TRPV1 modulator compounds of formula (I) or their pharmaceutically, veterinary or cosmetically acceptable salts, or their stereoisomers or mixtures thereof, wherein m is an integer selected from 1 to 3; R.sup.1, R.sup.2, R.sup.6 and R.sup.6 are independently selected from H, (C.sub.1-C.sub.8)alkyl, unsaturated (C.sub.2-C.sub.8)hydrocarbon, and (C.sub.3-C.sub.6)cycloalkyl, being these groups optionally substituted; R.sup.3 is hydrogen or halogen; R.sup.4 is selected from H, (C.sub.1-C.sub.8)alkyl, unsaturated (C.sub.2-C.sub.8)hydrocarbon, (C.sub.3-C.sub.6)cycloalkyl, (C.sub.6-C.sub.12)aryl, and (C.sub.5-C.sub.12)heteroaryl, being these groups optionally substituted; and R.sup.5 is selected from (C.sub.3-C.sub.28)alkyl, unsaturated (C.sub.3-C.sub.28)hydrocarbon, (C.sub.6-C.sub.12)aryl, and (C.sub.5-C.sub.12)heteroaryl, being these groups optionally substituted. It also relates to a process for their preparation, to pharmaceutical, veterinary or cosmetic compositions containing them, and to their pharmaceutical, veterinary and cosmetic applications.

##STR00001##

The present invention relates to TRPV1 modulator compounds of formula (I) or their pharmaceutically, veterinary or cosmetically acceptable salts, or their stereoisomers or mixtures thereof, wherein m is an integer selected from 1 to 3; R.sup.1, R.sup.2, R.sup.6 and R.sup.6 are independently selected from H, (C.sub.1-C.sub.8)alkyl, unsaturated (C.sub.2-C.sub.8)hydrocarbon, and (C.sub.3-C.sub.6)cycloalkyl, being these groups optionally substituted; R.sup.3 is hydrogen or halogen; R.sup.4 is selected from H, (C.sub.1-C.sub.8)alkyl, unsaturated (C.sub.2-C.sub.8)hydrocarbon, (C.sub.3-C.sub.6)cycloalkyl, (C.sub.6-C.sub.12)aryl, and (C.sub.5-C.sub.12)heteroaryl, being these groups optionally substituted; and R.sup.5 is selected from (C.sub.3-C.sub.28)alkyl, unsaturated (C.sub.3-C.sub.28)hydrocarbon, (C.sub.6-C.sub.12)aryl, and (C.sub.5-C.sub.12)heteroaryl, being these groups optionally substituted. It also relates to a process for their preparation, to pharmaceutical, veterinary or cosmetic compositions containing them, and to their pharmaceutical, veterinary and cosmetic applications.

##STR00001##

There are provided a surface-modified nanodiamond exhibiting easy dispersibility in an organic solvent, an organic solvent dispersion thereof, and a method for producing the surface-modified nanodiamond. The surface-modified nanodiamond according to the present invention includes a nanodiamond, and a group bound to a particulate surface of the nanodiamond and represented by formula (1):

NHCOR (1)

R is an organic group having a carbon atom at a binding site with a neighboring carbonyl carbon atom indicated in the formula; and the left end, in the formula, of the group serves to form bonding to the nanodiamond. The nanodiamond is preferably a detonation nanodiamond or a high-temperature high-pressure nanodiamond.

There are provided a surface-modified nanodiamond exhibiting easy dispersibility in an organic solvent, an organic solvent dispersion thereof, and a method for producing the surface-modified nanodiamond. The surface-modified nanodiamond according to the present invention includes a nanodiamond, and a group bound to a particulate surface of the nanodiamond and represented by formula (1):

NHCOR (1)

R is an organic group having a carbon atom at a binding site with a neighboring carbonyl carbon atom indicated in the formula; and the left end, in the formula, of the group serves to form bonding to the nanodiamond. The nanodiamond is preferably a detonation nanodiamond or a high-temperature high-pressure nanodiamond.

Disclosed are a method for preparing 2-aryl malonamide and an application thereof. This method uses 2-(cyclohexenylidene) malononitrile as a raw material, which undergoes an aromatization-hydrolyzation reaction in the presence of an oxidant and water to produce 2-aryl malonamide by one step. Compared to the prior art, the method for preparing 2-aryl malonamide of this application has the following features and advantages: (1) this method employs a completely different synthetic strategy; (2) raw materials used in this method are easily obtained; (3) this method not only has high yield, but also does not require expensive metal catalysts. This method is lower-cost, suitable for the industrial production.