The present invention relates to an amide compound solution comprising an amide compound and a surfactant. More specifically, the invention relates to an amide compound solution comprising amide compound, and 2.7˜20 mg of a cationic surfactant per 1 kg of the amide compound or 0.01˜10 mg of a C15˜C20 carboxylic acid or its salt as an anionic surfactant per 1 kg of the amide compound. The present invention provides an amide compound solution which is manufactured using a biocatalyst and which has a low level of foaming, and thereby improving the operability and yield when manufacturing an amide compound-based polymer.

The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.

The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.

There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application. ##STR00001##

There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application. ##STR00001##

There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application. ##STR00001##

The present invention provides a method of producing an aqueous solution containing bis(N.sup.ε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, and having a pH of 9-11, which includes a first step of reacting N.sup.ε-lauroyl lysine and/or a salt thereof with dicarboxylic acid dichloride in a water solvent having a pH of 12-14 to form bis(N.sup.ε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, a second step of adjusting the aqueous solution obtained in the first step to pH 7.5-8.5, a third step of adding N.sup.ε-lauroyl lysine to the aqueous solution obtained in the second step and filtering the mixture, and a fourth step of adjusting the aqueous solution obtained in the third step to pH 9-11.

The present invention provides a method of producing an aqueous solution containing bis(N.sup.ε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, and having a pH of 9-11, which includes a first step of reacting N.sup.ε-lauroyl lysine and/or a salt thereof with dicarboxylic acid dichloride in a water solvent having a pH of 12-14 to form bis(N.sup.ε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, a second step of adjusting the aqueous solution obtained in the first step to pH 7.5-8.5, a third step of adding N.sup.ε-lauroyl lysine to the aqueous solution obtained in the second step and filtering the mixture, and a fourth step of adjusting the aqueous solution obtained in the third step to pH 9-11.

The present invention provides a method of producing an aqueous solution containing bis(N.sup.ε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, and having a pH of 9-11, which includes a first step of reacting N.sup.ε-lauroyl lysine and/or a salt thereof with dicarboxylic acid dichloride in a water solvent having a pH of 12-14 to form bis(N.sup.ε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, a second step of adjusting the aqueous solution obtained in the first step to pH 7.5-8.5, a third step of adding N.sup.ε-lauroyl lysine to the aqueous solution obtained in the second step and filtering the mixture, and a fourth step of adjusting the aqueous solution obtained in the third step to pH 9-11.

The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.