Aspects of the disclosure includes methods for preparing an amorphous solid composition of a fatty acid metal salt. In practicing the subject methods according to certain embodiments, a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane organic salt is contacted with a metal base to produce a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt; and the succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt is precipitated in a solvent to produce an amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane metal salt composition. An amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt is also provided.

The present invention relates to new forms of co-crystals of agomelatine and p-toluenesulphonic acid, to a process for their preparation and to pharmaceutical compositions containing them. The co-crystals according to the invention have better solubility than agomelatine and are therefore more suitable for the preparation of pharmaceutical compositions. They also have better stability and purity and, moreover, are obtained by a simple process which does not include any difficult steps. ##STR00001##

The present invention relates to new forms of co-crystals of agomelatine and p-toluenesulphonic acid, to a process for their preparation and to pharmaceutical compositions containing them. The co-crystals according to the invention have better solubility than agomelatine and are therefore more suitable for the preparation of pharmaceutical compositions. They also have better stability and purity and, moreover, are obtained by a simple process which does not include any difficult steps. ##STR00001##

The present disclosure relates to a production method of a dicarboxylic acid compound and/or diamine compound, and optionally, dehydration condensates of the dicarboxylic acid compound and diamine compound (dehydration condensate of one molecule of the dicarboxylic acid compound and one molecule of the diamine compound and dehydration condensates of one molecule of one of these and two molecules of the other), from a polyamide as the raw material. It includes (i) a first hydrolysis step of hydrolyzing the polyamide in high-temperature water to obtain a first hydrolysate, and (ii) a second hydrolysis step of subjecting the first hydrolysate to enzymatic hydrolysis to obtain a second hydrolysate. The first hydrolysate contains a water-soluble polyamide that dissolves in water at 20 C., and the second hydrolysate contains the dicarboxylic acid compound and/or diamine compound, and optionally contains a dehydration condensate of the dicarboxylic acid compound and diamine compound.

The present disclosure relates to a production method of a dicarboxylic acid compound and/or diamine compound, and optionally, dehydration condensates of the dicarboxylic acid compound and diamine compound (dehydration condensate of one molecule of the dicarboxylic acid compound and one molecule of the diamine compound and dehydration condensates of one molecule of one of these and two molecules of the other), from a polyamide as the raw material. It includes (i) a first hydrolysis step of hydrolyzing the polyamide in high-temperature water to obtain a first hydrolysate, and (ii) a second hydrolysis step of subjecting the first hydrolysate to enzymatic hydrolysis to obtain a second hydrolysate. The first hydrolysate contains a water-soluble polyamide that dissolves in water at 20 C., and the second hydrolysate contains the dicarboxylic acid compound and/or diamine compound, and optionally contains a dehydration condensate of the dicarboxylic acid compound and diamine compound.

The invention relates to a novel process for making lisdexamfetamine dimesylate and related derivatives by the novel amino acid activation and amphetamine acylation in the presence of water or alcohols. A second invention relates to the novel process for making lisdexamfetamine dimesylate from racemic amphetamine compounds where the single isomer product is isolated without a chemical or enzymatic resolution.

The invention relates to a novel process for making lisdexamfetamine dimesylate and related derivatives by the novel amino acid activation and amphetamine acylation in the presence of water or alcohols. A second invention relates to the novel process for making lisdexamfetamine dimesylate from racemic amphetamine compounds where the single isomer product is isolated without a chemical or enzymatic resolution.

An amido group-containing monomer composition contains 80.00 to 99.99 mass % of an amido group-containing monomer (a) of the following formula (1) and 0.01 to 20.00 mass % of a metal chelate complex (b) having carbonyl group as a ligand:

##STR00001##

wherein R.sup.1 represents a hydrogen atom or a methyl group, R.sup.2 represents a hydrocarbon group having a carbon number of 1 to 6, R.sup.3 represents a hydrocarbon group having a carbon number of 1 to 23, and R.sup.4 represents hydrogen or a methyl group.

An amido group-containing monomer composition contains 80.00 to 99.99 mass % of an amido group-containing monomer (a) of the following formula (1) and 0.01 to 20.00 mass % of a metal chelate complex (b) having carbonyl group as a ligand:

##STR00001##

wherein R.sup.1 represents a hydrogen atom or a methyl group, R.sup.2 represents a hydrocarbon group having a carbon number of 1 to 6, R.sup.3 represents a hydrocarbon group having a carbon number of 1 to 23, and R.sup.4 represents hydrogen or a methyl group.

The present invention relates to a process for obtaining amidated fatty acids or derivatives thereof good in color even after longer storage with low concentrations of undesired by-products. The present invention also relates to use of amidated fatty acids or derivatives thereof obtained by the process in the cosmetic applications. Further, the present invention also relates to use of amidated fatty acids or derivatives thereof obtained by the process in the industrial applications.