The invention provides a compound of formula I, formula II, or formula III: ##STR00001##
or a salt thereof, wherein R.sup.1-R.sup.10 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as HIV-1 CA-targeting molecules and as antiviral agents.

The invention provides a compound of formula I, formula II, or formula III: ##STR00001##
or a salt thereof, wherein R.sup.1-R.sup.10 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as HIV-1 CA-targeting molecules and as antiviral agents.

The present invention relates to hyper-branched compounds, a method of synthesizing the hyper-branched compounds and applications of the hyper-branched compounds. The hyper-branched compounds of the present invention include hyper-branched fluorinated compounds, hyper-branched fluorinated graphene and hyper-branched amine functionalized graphene oxide.

Disclosed herein are compounds for activating the Reelin signaling system for the treatment of neurological disorders. Further provided are compounds and methods for activating a lipoprotein receptor, such as ApoER2 or VLDLR.

Disclosed herein are compounds for activating the Reelin signaling system for the treatment of neurological disorders. Further provided are compounds and methods for activating a lipoprotein receptor, such as ApoER2 or VLDLR.

The present invention provides a 1,4-disubstituted imidazole derivative of formula (1) wherein ring Q.sup.1 is optionally-substituted C.sub.6-10 aryl group, etc.; R.sup.1 and R.sup.2 are independently hydrogen atom, etc.; W.sup.1 is optionally-substituted C.sub.1-4 alkylene group; W.sup.2 is NR.sup.3aC(O) wherein R.sup.3a is hydrogen atom or C.sub.1-6alkyl group, etc.; ring Q.sup.2 is 5- to 10-membered heteroaryl group, etc.; W.sup.3 is optionally-substituted C.sub.1-4 alkylene group, etc.; n is 1, 2, 3, 4, or 5; R.sup.4 is independently halogen atom, optionally-substituted C.sub.1-6 alkyl group, etc.; R.sup.5 is hydroxy group, etc.; and a pharmacologically acceptable salt thereof, which have a potent inhibitory effect on the sphere-forming capacity of cancer cells and are useful as an orally-available anti-tumor agent. ##STR00001##

The present invention provides a 1,4-disubstituted imidazole derivative of formula (1) wherein ring Q.sup.1 is optionally-substituted C.sub.6-10 aryl group, etc.; R.sup.1 and R.sup.2 are independently hydrogen atom, etc.; W.sup.1 is optionally-substituted C.sub.1-4 alkylene group; W.sup.2 is NR.sup.3aC(O) wherein R.sup.3a is hydrogen atom or C.sub.1-6alkyl group, etc.; ring Q.sup.2 is 5- to 10-membered heteroaryl group, etc.; W.sup.3 is optionally-substituted C.sub.1-4 alkylene group, etc.; n is 1, 2, 3, 4, or 5; R.sup.4 is independently halogen atom, optionally-substituted C.sub.1-6 alkyl group, etc.; R.sup.5 is hydroxy group, etc.; and a pharmacologically acceptable salt thereof, which have a potent inhibitory effect on the sphere-forming capacity of cancer cells and are useful as an orally-available anti-tumor agent. ##STR00001##

The present invention relates to a novel compound showing leukotriene B4 receptor 2 (BLT2) inhibitory activity and a pharmaceutical composition, for preventing or treating inflammatory diseases, having same as an active ingredient. The inventors identified a novel compound containing BTL2 inhibitory activity, and experimentally confirmed that the present novel compound had an excellent effect on the enhancement of the cancer cell death, on the inhibition of the metastasis and chemotactic mobility, and on the anti-asthma activity. Therefore, the present novel compound can be used as a very effective pharmaceutical component for treating the inflammatory-related diseases.

The present invention relates to a novel compound showing leukotriene B4 receptor 2 (BLT2) inhibitory activity and a pharmaceutical composition, for preventing or treating inflammatory diseases, having same as an active ingredient. The inventors identified a novel compound containing BTL2 inhibitory activity, and experimentally confirmed that the present novel compound had an excellent effect on the enhancement of the cancer cell death, on the inhibition of the metastasis and chemotactic mobility, and on the anti-asthma activity. Therefore, the present novel compound can be used as a very effective pharmaceutical component for treating the inflammatory-related diseases.

Provided are m-diamide compounds and a preparation method therefor and the use thereof. The m-diamide compounds have a structure represented by formula I. The m-diamide compounds of the present invention can have a high insecticidal activity at a low dose and take effect rapidly, can exert the insecticidal activity one day after application, can achieve a high insecticidal activity within three days, and have a good fast-acting property; moreover, due to the good effect at a low dose, the m-diamide compounds can reduce the damage to plants and human beings caused by excessive drug concentrations, enable less drug residue to be generated during application which is more conducive to environmental protection, and have broad application prospects.