The present disclosure provides compounds and pharmaceutically acceptable salts thereof, and methods of using the same. The compounds and methods have a range of utilities as therapeutics, diagnostics, and research tools. In particular, the subject compositions and methods are useful for reducing signaling output of oncogenic proteins.

The invention provides synthetic methods and synthetic intermediates that are useful for preparing the antibacterial compound:

##STR00001##

The invention provides synthetic methods and synthetic intermediates that are useful for preparing the antibacterial compound:

##STR00001##

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof. ##STR00001##

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof. ##STR00001##

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof. ##STR00001##

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof. ##STR00001##

The invention provides compounds of formula (I): ##STR00001##
wherein R.sup.1-R.sup.3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

The invention provides compounds of formula (I): ##STR00001##
wherein R.sup.1-R.sup.3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

The invention provides compounds of formula (I):

##STR00001##

wherein R.sup.1-R.sup.3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.