The invention provides compounds of formula (I):

##STR00001##

wherein R.sup.1-R.sup.3, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

##STR00001##

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.

##STR00001##

The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.

The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.

The present invention provides compounds of formula (I), and pharmaceutical compositions thereof. ##STR00001##

The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula (formula I) wherein R.sub.1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C-atoms; and X is selected from the group consisting of moieties X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5 and X.sub.6. Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease. ##STR00001##

The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula (formula I) wherein R.sub.1 is H or a saturated or unsaturated aliphatic moiety comprising 1 to 8 C-atoms; and X is selected from the group consisting of moieties X.sub.1, X.sub.2, X.sub.3, X.sub.4, X.sub.5 and X.sub.6. Exemplary uses include the prevention or therapeutic treatment of a HSF1-mediated disease. ##STR00001##

Novel methods for the production of enantiomerically pure (EP) -lactams by decomposition of -diazo--ketoamides.

Novel methods for the production of enantiomerically pure (EP) -lactams by decomposition of -diazo--ketoamides.