Cell binding agent-drug conjugates comprising bridge linkers, and methods of using such linkers and conjugates are provided.

Described are devices, compounds and methods for detecting an analyte in a sample. More particularly this disclosure provides SPR and LSPR sensors modified by NTA linkers for binding a ligand and/or analyte. The NTA linkers of the disclosure typically include a head (or anchoring site) for coupling to a surface of the SPR or LSPR sensor, a spacer, and one or more attachment sites on a distal end or ends of the spacer which couple to a ligand. The head may include a thiol for coupling the linker to a surface of the SPR or LSPR sensor. The spacer may be a carbon chain. PAG or PEG chain, or matrix material. The one or more attachment sites may be a nitrilotriacetic acid (NTA) moiety capable of chelating a transition metal ion and binding the ligand.

Described are devices, compounds and methods for detecting an analyte in a sample. More particularly this disclosure provides SPR and LSPR sensors modified by NTA linkers for binding a ligand and/or analyte. The NTA linkers of the disclosure typically include a head (or anchoring site) for coupling to a surface of the SPR or LSPR sensor, a spacer, and one or more attachment sites on a distal end or ends of the spacer which couple to a ligand. The head may include a thiol for coupling the linker to a surface of the SPR or LSPR sensor. The spacer may be a carbon chain. PAG or PEG chain, or matrix material. The one or more attachment sites may be a nitrilotriacetic acid (NTA) moiety capable of chelating a transition metal ion and binding the ligand.

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

##STR00001##

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

##STR00001##

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

##STR00001##

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).

##STR00001##

Cell binding agent-drug conjugates comprising bridge linkers, and methods of using such linkers and conjugates are provided.

Cell binding agent-drug conjugates comprising bridge linkers, and methods of using such linkers and conjugates are provided.

Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.