The present disclosure relates to a method for preparing acrylonitrile dimer.

A porous polymer has a pore volume of 0.3 to 2.5 cm.sup.3/g and comprises a pore having a first pore diameter and a pore having a second pore diameter. A ratio of pore volume of the pore having a first pore diameter to pore volume of the pore having a second pore diameter is 1 to 10:1. The porous polymer is obtained by self-polymerization or copolymerization of at least one of the phosphorus ligands, and phosphorous content of the porous polymer is 1 to 5 mmol/g. The porous polymer-nickel catalyst made of the porous polymer has a significant increase in water resistance, which may reduce the consumption of phosphorus ligands, eliminating the steps of removing water from raw materials and reaction system water control, which greatly saves process equipment investment. When used in the preparation of adiponitrile from butadiene, it has high catalytic activity, high reaction selectivity, and high linearity.

A porous polymer has a pore volume of 0.3 to 2.5 cm.sup.3/g and comprises a pore having a first pore diameter and a pore having a second pore diameter. A ratio of pore volume of the pore having a first pore diameter to pore volume of the pore having a second pore diameter is 1 to 10:1. The porous polymer is obtained by self-polymerization or copolymerization of at least one of the phosphorus ligands, and phosphorous content of the porous polymer is 1 to 5 mmol/g. The porous polymer-nickel catalyst made of the porous polymer has a significant increase in water resistance, which may reduce the consumption of phosphorus ligands, eliminating the steps of removing water from raw materials and reaction system water control, which greatly saves process equipment investment. When used in the preparation of adiponitrile from butadiene, it has high catalytic activity, high reaction selectivity, and high linearity.

An embodiment of the present invention provides a method for preparing a phthalonitrile-based compound, comprising: (a) feeding a mixture comprising a phthalic acid-based compound and a nitrile-based compound into a first reaction part to react; (b) transferring a resulting product of step (a) to a second reaction part connected to the first reaction part to react under the condition of 350 to 400° C.; and (c) obtaining a phthalonitrile-based compound at a discharge part connected to the second reaction part, wherein the second reaction part has a length in a fluid flow direction which is 10 times or more of a square root of an average cross-sectional area perpendicular to the fluid flow direction.

An embodiment of the present invention provides a method for preparing a phthalonitrile-based compound, comprising: (a) feeding a mixture comprising a phthalic acid-based compound and a nitrile-based compound into a first reaction part to react; (b) transferring a resulting product of step (a) to a second reaction part connected to the first reaction part to react under the condition of 350 to 400° C.; and (c) obtaining a phthalonitrile-based compound at a discharge part connected to the second reaction part, wherein the second reaction part has a length in a fluid flow direction which is 10 times or more of a square root of an average cross-sectional area perpendicular to the fluid flow direction.

An embodiment of the present invention provides a method for preparing a phthalonitrile-based compound, comprising: (a) feeding a mixture comprising a phthalic acid-based compound and a nitrile-based compound into a first reaction part to react; (b) transferring a resulting product of step (a) to a second reaction part connected to the first reaction part to react under the condition of 350 to 400° C.; and (c) obtaining a phthalonitrile-based compound at a discharge part connected to the second reaction part, wherein the second reaction part has a length in a fluid flow direction which is 10 times or more of a square root of an average cross-sectional area perpendicular to the fluid flow direction.

The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar—Ar′ by photochemically reacting a precursor compound of formula (II): Ar—L—Ar′ to form a biaryl compound of general formula: Ar—L—Ar′(II).fwdarw.Ar—Ar′ (I) wherein Ar and Ar′, independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5-20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group —X—Y—Z— as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities. Their use within the field of synthesis of active ingredients is an aspect of the invention, and their use in the preparation of pharmaceutically active ingredients is particularly preferred.

The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar—Ar′ by photochemically reacting a precursor compound of formula (II): Ar—L—Ar′ to form a biaryl compound of general formula: Ar—L—Ar′(II).fwdarw.Ar—Ar′ (I) wherein Ar and Ar′, independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5-20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group —X—Y—Z— as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities. Their use within the field of synthesis of active ingredients is an aspect of the invention, and their use in the preparation of pharmaceutically active ingredients is particularly preferred.

In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.