The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). The present invention also sets forth methods for inhibiting FAAH as well as methods for treating conditions such as, but not limited to, pain, inflammation, immune disorders, dermatitis, mucositis, the over reactivity of peripheral sensory neurons, neurodermatitis, and an overactive bladder. Accordingly, the invention also provides compounds, methods, and pharmaceutical compositions for treating conditions in which the selective inhibition of peripheral FAAH (as opposed to CNS FAAH) would be of benefit.

The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). The present invention also sets forth methods for inhibiting FAAH as well as methods for treating conditions such as, but not limited to, pain, inflammation, immune disorders, dermatitis, mucositis, the over reactivity of peripheral sensory neurons, neurodermatitis, and an overactive bladder. Accordingly, the invention also provides compounds, methods, and pharmaceutical compositions for treating conditions in which the selective inhibition of peripheral FAAH (as opposed to CNS FAAH) would be of benefit.

Described herein is a process for preparing urethane (meth)acrylates. In a first step, a hydroxyalkyl (meth)acrylate is reacted with a lactone (B) in the presence of at least one zinc compound and/or bismuth compound (C) to produce a resulting zinc-containing product and/or a bismuth-containing product, and, in a further step, the zinc-containing product and/or the bismuth-containing product is reacted with at least one cycloaliphatic or asymmetric aliphatic diisocyanate (D).

Described herein is a process for preparing urethane (meth)acrylates. In a first step, a hydroxyalkyl (meth)acrylate is reacted with a lactone (B) in the presence of at least one zinc compound and/or bismuth compound (C) to produce a resulting zinc-containing product and/or a bismuth-containing product, and, in a further step, the zinc-containing product and/or the bismuth-containing product is reacted with at least one cycloaliphatic or asymmetric aliphatic diisocyanate (D).

A compound of formula (I)

##STR00001##

wherein n is selected from 3 to 8 and R is hydrogen or a C.sub.1-C.sub.8 alkyl radical, a process for the preparation of the compound and uses of the compound.

A compound of formula (I)

##STR00001##

wherein n is selected from 3 to 8 and R is hydrogen or a C.sub.1-C.sub.8 alkyl radical, a process for the preparation of the compound and uses of the compound.

Described herein is a bismuth-containing catalyser, which is defined by a general formula (I). The bismuth-containing catalyser includes at least one radical R1, which includes a carboxyl fragment according to the general formula (II), where a first carbon atom (α-carbon) is bonded to the carbon atom of the carboxyl group, which in turn is directly substituted with at least one aromatic system. Also described herein is a method for preparing the bismuth-containing catalyser and a method of using the bismuth-containing catalyser for preparing compounds including a urethane group.

Described herein is a bismuth-containing catalyser, which is defined by a general formula (I). The bismuth-containing catalyser includes at least one radical R1, which includes a carboxyl fragment according to the general formula (II), where a first carbon atom (α-carbon) is bonded to the carbon atom of the carboxyl group, which in turn is directly substituted with at least one aromatic system. Also described herein is a method for preparing the bismuth-containing catalyser and a method of using the bismuth-containing catalyser for preparing compounds including a urethane group.

The composition comprises a compound (A) represented by general formula (1) and a compound (B) represented by general formula (2), and comprises 0.00002 to 2.0 parts by mass of the compound (B) with respect to 100 parts by mass of the compound (A),

(R.sub.1—COO).sub.n—R.sub.2—(NCO).sub.m   (1)

g(R.sub.1—COO).sub.n—R.sub.2—NHC(═O)NH—R.sub.2—(OCO—R.sub.1).sub.m   (2)

wherein in general formulae (1) and (2), R.sub.1 is an ethylenically unsaturated group having 2 to 7 carbon atoms; R.sub.2 is a (m+n)-valent hydrocarbon group having 1 to 7 carbon atoms and optionally contain an ether group; R.sub.1 and R.sub.2 in the general formula (1) are the same as R.sub.1 and R.sub.2 in the general formula (2); and n and m each represent an integer of one or two.

The composition comprises a compound (A) represented by general formula (1) and a compound (B) represented by general formula (2), and comprises 0.00002 to 2.0 parts by mass of the compound (B) with respect to 100 parts by mass of the compound (A),

(R.sub.1—COO).sub.n—R.sub.2—(NCO).sub.m   (1)

g(R.sub.1—COO).sub.n—R.sub.2—NHC(═O)NH—R.sub.2—(OCO—R.sub.1).sub.m   (2)

wherein in general formulae (1) and (2), R.sub.1 is an ethylenically unsaturated group having 2 to 7 carbon atoms; R.sub.2 is a (m+n)-valent hydrocarbon group having 1 to 7 carbon atoms and optionally contain an ether group; R.sub.1 and R.sub.2 in the general formula (1) are the same as R.sub.1 and R.sub.2 in the general formula (2); and n and m each represent an integer of one or two.