Disclosed is a method for the integrated production of two different urea products. One is an aqueous urea solution suitable for use in NOx abatement (generally indicated as Diesel Exhaust Fluid DEF). The other is a solution used as a fertilizer, viz. Urea Ammonium Nitrate (UAN). The production of DEF and UAN are integrated as follows: ammonia recovered from the production of urea is used as a feed to the production of ammonium nitrate. At least part of an aqueous urea stream from urea production, is mixed with ammonium nitrate so as to obtain UAN.

A novel solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea hydrochloride (also referred to ATR-101) suitable for oral dosing, and to compositions, methods and kits relating thereto. ATR-101 has particular utility in the treatment of, for example, aberrant adrenocortical cellular activity, including adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH) and Cushing's syndrome.

This invention provides for synthesis of citrulline from a transition metal complex of ornithine using cyanate to derivatize the terminal amino group of ornithine. The invention also provides improved methods for purification of citrulline produced by reaction of cyanate with ornithine via the steps of reprecipitation of copper complex of citrulline, removal of the complexing metal by sulfide precipitation, activated carbon adsorption and antisolvent crystallization.

A one-pot synthesis of polymerizable and acyclic urea (meth)acrylates, preferably mono(meth)acrylates, can be performed via in-situ synthesis of urea alcohols or amines followed by direct reaction with a (meth)acrylate reactive diluent. The urea alcohol/amine is obtained from isocyanates and alcohols, amines, or hydroxyamines. Subsequently, the reaction with the (meth)acrylate reactive diluent takes place and the urea (meth)acrylate is directly obtained either in solution with the reactive diluent, or as a pure material after removal of the reactive diluent.

Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.

The present invention provides a process for preparing a compound having the formula (I): ##STR00001## wherein R is alkyl or alkylaryl; each of X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5 is, independently, H, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, dialkylamino, alkoxycarbonyl, alkyl carbonyl, hydroxyalkyl, ester, acid halogen, SH, OH, NH.sub.2, NO.sub.2, CN or CF.sub.3; Y is O or S; and and Z is a halogen.

The present invention provides a process for preparing a compound having the formula (I):

##STR00001## wherein R is alkyl or alkylaryl; each of X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5 is, independently, H, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, alkylthio, haloalkylthio, amino, alkylamino, dialkylamino, alkoxycarbonyl, alkyl carbonyl, hydroxyalkyl, ester, acid halogen, SH, OH, NH.sub.2, NO.sub.2, CN or CF.sub.3; Y is O or S; and and Z is a halogen.

A method for producing a carbamic acid salt, including contacting a carbon dioxide-containing mixed gas having a partial pressure of carbon dioxide of 0.001 atm or more and less than 1 atm with an amino group-containing organic compound in the presence of a base in at least one organic solvent selected from the group consisting of an organic solvent having 2 or more and 8 or less carbon atoms, and a method for producing a carbamic acid ester or a urea derivative using the carbamic acid salt.

The original abstract is amended to A method for self-catalytic directional degradation of polyurethane material includes performing a crushing step, performing a mixing step, performing a degradation step, and performing a heating and pressure reduction step. In the crushing step, the polyurethane material is crushed to form several polyurethane particles. In a mixing step, the several polyurethane particles are mixed with an alcoholamine compound to form a degradation system, and the alcoholamine compound has a structure represented by formula (I) or formula (II), of which each symbol is defined in the specification. In the degradation step, the degradation system is degraded at a reaction temperature to obtain an intermediate product. In the heating and pressure reduction step, the intermediate product is under the reaction temperature and a reduced reaction pressure to remove an excess portion of the alcoholamine compound, so as to obtain a polyol.