A method for preparing guanidino acetic acid involves reacting cyanamide and glycine in an aqueous reaction mixture in the presence of a base. The ammonia content in the reaction mixture is controlled to be below 20 g/L, and the dicyandiatrade content in the reaction mixture is kept below 5 wt.-%.

The invention relates to the field of pharmaceutical chemistry, namely to new biologically active substances and their use and to a method of production. In particular, the invention relates to a derivative of creatinephenylcreatine, its use as a functional analogue of creatine, as well as a nootropic agent and for the prevention or treatment of arrhythmia and a method of its production.

The invention relates to the field of pharmaceutical chemistry, namely to new biologically active substances and their use and to a method of production. In particular, the invention relates to a derivative of creatinephenylcreatine, its use as a functional analogue of creatine, as well as a nootropic agent and for the prevention or treatment of arrhythmia and a method of its production.

Provided herein is a process and intermediates for the preparation of a compound of formula (I): or a pharmaceutically acceptable salt thereof, using cyanamide in the reaction. ##STR00001##

Provided herein is a process and intermediates for the preparation of a compound of formula (I): or a pharmaceutically acceptable salt thereof, using cyanamide in the reaction. ##STR00001##

The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; a crystalline solid form of the compound of formula (I), in particular crystalline solid form A; to a pharmaceutical composition comprising them; and to their use as a medicament, in particular to the treatment of a condition mediated by Rho-GTPase cell proteins. ##STR00001##

The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; a crystalline solid form of the compound of formula (I), in particular crystalline solid form A; to a pharmaceutical composition comprising them; and to their use as a medicament, in particular to the treatment of a condition mediated by Rho-GTPase cell proteins. ##STR00001##

Solar energy device comprising at least one of a photovoltaic cell or a solar thermal collector having an absorption bandwidth in the infrared wavelength region of the solar spectrum; a visible light-transmitting reflector; and at least one of a graphic film or lighted display. The graphic film or a lighted display present is visible through the visible light-transmitting reflector. The solar energy devices can be used, for example, as a sign (e.g., an advertising sign or a traffic sign), on the side and/or roof, as well as in a window, of a building.

Solar energy device comprising at least one of a photovoltaic cell or a solar thermal collector having an absorption bandwidth in the infrared wavelength region of the solar spectrum; a visible light-transmitting reflector; and at least one of a graphic film or lighted display. The graphic film or a lighted display present is visible through the visible light-transmitting reflector. The solar energy devices can be used, for example, as a sign (e.g., an advertising sign or a traffic sign), on the side and/or roof, as well as in a window, of a building.

Solar energy device (100) comprising at least one of a photovoltaic cell or a solar thermal collector (101) having an absorption bandwidth in the infrared wavelength region of the solar spectrum; a visible light-transmitting reflector (103); and at least one of a graphic film or lighted display (105). The graphic film or a lighted display present is visible through the visible light-transmitting reflector. The solar energy devices can be used, for example, as a sign (e.g., an advertising sign or a traffic sign), on the side and/or roof, as well as in a window, of a building.