The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp.

##STR00001##

A method for preparing a compound of formula (I) ##STR00001## in which R1 is selected from H and alkyls, R2 is selected from H, alkyls, OR′ where R′ is selected from alkyls, silyls, CO-alkyl, R3 is selected from the acyl groups of the CO(R″) type, and the CO(OR″), CO(NR″R′″), PO(OR″)(OR′″), PO(OR″)(R′″) groups where R″ and R′″, independently of each other, are selected from H and alkyls, R represents a C(R4)═C(R5)(R6) group where R4, R5 and R6, independently of each other, are selected from H, linear or cyclic alkyls and alkenyls, aryls, alkylaryls, or R4 and R5 together form a saturated or unsaturated, substituted or unsubstituted ring, from a compound of formula (II) ##STR00002## or a compound of formula (III) ##STR00003## in which, R, R1, R2 and R3 have the above definition.

A method for preparing a compound of formula (I) ##STR00001## in which R1 is selected from H and alkyls, R2 is selected from H, alkyls, OR′ where R′ is selected from alkyls, silyls, CO-alkyl, R3 is selected from the acyl groups of the CO(R″) type, and the CO(OR″), CO(NR″R′″), PO(OR″)(OR′″), PO(OR″)(R′″) groups where R″ and R′″, independently of each other, are selected from H and alkyls, R represents a C(R4)═C(R5)(R6) group where R4, R5 and R6, independently of each other, are selected from H, linear or cyclic alkyls and alkenyls, aryls, alkylaryls, or R4 and R5 together form a saturated or unsaturated, substituted or unsubstituted ring, from a compound of formula (II) ##STR00002## or a compound of formula (III) ##STR00003## in which, R, R1, R2 and R3 have the above definition.

The present disclosure relates to methods of carbon-carbon bond fragmentation.

The present disclosure relates to methods of carbon-carbon bond fragmentation.

A process for the preparation of trifluoromethanesulfinyl chloride is provided. Trifluoromethanesulfinyl chloride is used as an intermediate for preparing pesticides and insecticides. Trifluoromethanesulfinyl chloride is represented by Formula I:

##STR00001##

The process for the preparation of trifluoromethanesulfinyl chloride employs readily available reagents and does not involve formation of toxic by-products, and is thus a simple, economic, and environmental-friendly process for the preparation of trifluoromethanesulfinyl chloride.

A process for the preparation of trifluoromethanesulfinyl chloride is provided. Trifluoromethanesulfinyl chloride is used as an intermediate for preparing pesticides and insecticides. Trifluoromethanesulfinyl chloride is represented by Formula I:

##STR00001##

The process for the preparation of trifluoromethanesulfinyl chloride employs readily available reagents and does not involve formation of toxic by-products, and is thus a simple, economic, and environmental-friendly process for the preparation of trifluoromethanesulfinyl chloride.

The invention relates to a process for producing 4,4′-dichlorodiphenyl sulfoxide comprising: (a) reacting thionyl chloride, chlorobenzene and aluminum chloride in a molar ratio of thionyl chloride:chlorobenzene:aluminum chloride of 1:(6 to 9):(1 to 1.5) at a temperature in the range from 0 to below 20° C., forming an intermediate reaction product and hydrogen chloride, (b) mixing aqueous hydrochloric acid and the intermediate reaction product at a temperature in the range from 70 to 110° C. to obtain a crude reaction product comprising 4,4′-dichlorodiphenyl sulfoxide, (c) separating the crude reaction product into an organic phase comprising the 4,4′-dichlorodiphenyl sulfoxide and an aqueous phase, (d) washing the organic phase with an extraction liquid.

The invention relates to a process for producing 4,4′-dichlorodiphenyl sulfoxide comprising: (a) reacting thionyl chloride, chlorobenzene and aluminum chloride in a molar ratio of thionyl chloride:chlorobenzene:aluminum chloride of 1:(6 to 9):(1 to 1.5) at a temperature in the range from 0 to below 20° C., forming an intermediate reaction product and hydrogen chloride, (b) mixing aqueous hydrochloric acid and the intermediate reaction product at a temperature in the range from 70 to 110° C. to obtain a crude reaction product comprising 4,4′-dichlorodiphenyl sulfoxide, (c) separating the crude reaction product into an organic phase comprising the 4,4′-dichlorodiphenyl sulfoxide and an aqueous phase, (d) washing the organic phase with an extraction liquid.

The present invention relates to the field of catalysts, and provides a porous layered transition metal dichalcogenide (TMD) and a preparation method and use thereof. The preparation method includes the following steps: (1) mixing silica microspheres, a transition metal salt and an elemental chalcogen, and pressing to obtain a tablet, the silica microspheres having a same or different particle diameters; and (2) sintering the tablet under hydrogen, and removing the silica microspheres to obtain the porous layered TMD. The porous layered TMD prepared by the method of the present invention has a high lattice edge exposure, which provides more active sites and higher catalytic activity, so the porous layered TMD can effectively catalyze the oxidation of alcohols to aldehydes or sulfides to sulfoxides under visible light irradiation.