The invention relates to a method of preparing arylvinylsulphones. The method comprises forming o a first reaction mixture comprising a catalyst complex of Cu(I)halide and a ligand, wherein the ligand is selected from mono-, bi- or polydentate amine ligands and further comprises an organic sulphonate; a reactive solvent selected from (meth)acrylonitrile or alkyl (meth)acrylate; and an aryl sulfonyl halide reactant. A reaction is allowed to proceed in the first reaction mixture at an elevated temperature, whereby an intermediate product is obtained. The unreacted reactive solvent is separated from the first reaction mixture, and the intermediate product is dissolved to a low polarity solvent to form a second reaction mixture. A base is added to the second reaction mixture, wherein the intermediate product undergoes a base-catalyzed elimination of the halogen atom from the intermediate product to form the compound according to Formula (I), preferably under cooling. Finally, the desired compound is separated from the second reaction mixture.

The invention relates to a method of preparing arylvinylsulphones. The method comprises forming o a first reaction mixture comprising a catalyst complex of Cu(I)halide and a ligand, wherein the ligand is selected from mono-, bi- or polydentate amine ligands and further comprises an organic sulphonate; a reactive solvent selected from (meth)acrylonitrile or alkyl (meth)acrylate; and an aryl sulfonyl halide reactant. A reaction is allowed to proceed in the first reaction mixture at an elevated temperature, whereby an intermediate product is obtained. The unreacted reactive solvent is separated from the first reaction mixture, and the intermediate product is dissolved to a low polarity solvent to form a second reaction mixture. A base is added to the second reaction mixture, wherein the intermediate product undergoes a base-catalyzed elimination of the halogen atom from the intermediate product to form the compound according to Formula (I), preferably under cooling. Finally, the desired compound is separated from the second reaction mixture.

Provided is an improved process of vitamin K2 derivatives preparation, represented by formula (I) wherein n is an integer from 3 to 13.

##STR00001##

Provided is an improved process of vitamin K2 derivatives preparation, represented by formula (I) wherein n is an integer from 3 to 13.

##STR00001##

The present invention relates to disubstituted 5(3)-pyrazole carboxylates of the formula (Ia) or (Ib) and a process for their preparation

##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are defined as above.

The present invention relates to disubstituted 5(3)-pyrazole carboxylates of the formula (Ia) or (Ib) and a process for their preparation

##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are defined as above.

The present invention relates to disubstituted 5(3)-pyrazole carboxylates of the formula (Ia) or (Ib) and a process for their preparation

##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n are defined as above.

A cyclopropanation method includes reacting an alcohol, an ester, or an aldehyde with a sulfone in an organic solvent containing a base providing a counter cation to form a cyclopropane; and isolating the cyclopropane. When using the alcohol or ester, the organic solvent further contains a catalyst having an alcohol dehydrogenation activity.

A cyclopropanation method includes reacting an alcohol, an ester, or an aldehyde with a sulfone in an organic solvent containing a base providing a counter cation to form a cyclopropane; and isolating the cyclopropane. When using the alcohol or ester, the organic solvent further contains a catalyst having an alcohol dehydrogenation activity.

A cyclopropanation method includes reacting an alcohol, an ester, or an aldehyde with a sulfone in an organic solvent containing a base providing a counter cation to form a cyclopropane; and isolating the cyclopropane. When using the alcohol or ester, the organic solvent further contains a catalyst having an alcohol dehydrogenation activity.