Patent classifications
C07C319/14
Large-scale diastereoselective syntheses of cycloheptadienylsulfones and stereotetrads
The invention relates to processes for large-scale diastereoselective syntheses of cycloheptadienylsulfone and stereotetrads, key intermediates for the preparation of Aplyronine A.
PREPARATION OF SULFONAMIDE HERBICIDE PROCESS INTERMEDIATES
Improved methods for preparing chemical precursors to sulfonyl chloride III, which are important intermediates in the preparation of pyroxsulam herbicide are provided. Specifically, these precursors are compounds of Formulas VII and/or VIII, and IX, wherein R is a C.sub.1-C.sub.6 alkyl, R.sup.1 is a C.sub.1-C.sub.6 alkyl, X is Cl or OH, Y is halogen, OH, or OR.sup.2, and R.sup.2 is a C.sub.1-C.sub.6 alkyl.
##STR00001##
PREPARATION OF SULFONAMIDE HERBICIDE PROCESS INTERMEDIATES
Improved methods for preparing chemical precursors to sulfonyl chloride III, which are important intermediates in the preparation of pyroxsulam herbicide are provided. Specifically, these precursors are compounds of Formulas VII and/or VIII, and IX, wherein R is a C.sub.1-C.sub.6 alkyl, R.sup.1 is a C.sub.1-C.sub.6 alkyl, X is Cl or OH, Y is halogen, OH, or OR.sup.2, and R.sup.2 is a C.sub.1-C.sub.6 alkyl.
##STR00001##
One-pot organo-pseudocatalytic C—H activation approach for the preparation of vortioxetine and vortioxetine intermediate
The present invention relates to a novel process for the preparation of Vortioxetine and a key intermediate thereof by employing a novel one-pot organo-pseudocatalytic C—H activation approach via hypervalent iodine chemistry.
One-pot organo-pseudocatalytic C—H activation approach for the preparation of vortioxetine and vortioxetine intermediate
The present invention relates to a novel process for the preparation of Vortioxetine and a key intermediate thereof by employing a novel one-pot organo-pseudocatalytic C—H activation approach via hypervalent iodine chemistry.
One-pot organo-pseudocatalytic C—H activation approach for the preparation of vortioxetine and vortioxetine intermediate
The present invention relates to a novel process for the preparation of Vortioxetine and a key intermediate thereof by employing a novel one-pot organo-pseudocatalytic C—H activation approach via hypervalent iodine chemistry.
PROCESS FOR MAKING HEPATITIS B CORE PROTEIN MODULATORS
The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp.
##STR00001##
PROCESS FOR MAKING HEPATITIS B CORE PROTEIN MODULATORS
The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp.
##STR00001##
Synthesis of fluoro hemiacetals via transition metal-catalyzed fluoro ester and carboxamide hydrogenation
This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.
Synthesis of fluoro hemiacetals via transition metal-catalyzed fluoro ester and carboxamide hydrogenation
This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.