The present invention includes methods for making and isolating N-acetylcysteine amide, (2R,2R)-3,3-disulfanediyl bis(2-acetamidopropanamide, diNACA), intermediates and derivatives thereof comprising: contacting cystine with an alcohol and a chlorinating reagent to form an organic solution containing L-cystine dimethylester dihydrochloride; combining dried or undried L-cystine dimethylester dihydrochloride with a triethylamine, an acetic anhydride, and an acetonitrile to form a di-N-acetylcystine dimethylester; mixing dried di-N-acetylcystine dimethylester with ammonium hydroxide to form a di-N-acetylcystine amide (diNACA); and separating dried di-N-acetylcystine dimethylester into N-acetylcysteine amide with dithiothreitol, triethylamine and an alcohol.

The present invention relates to a novel compound exhibiting anti-oxidative or anti-inflammatory activity, a method of preparing the compound, a pharmaceutical composition for preventing or treating inflammatory diseases or the diseases caused by oxidation, which comprises the compound or a salt thereof as an active ingredient, and an anti-inflammatory or anti-oxidative cosmetic composition or food composition.

The present invention relates to a novel compound exhibiting anti-oxidative or anti-inflammatory activity, a method of preparing the compound, a pharmaceutical composition for preventing or treating inflammatory diseases or the diseases caused by oxidation, which comprises the compound or a salt thereof as an active ingredient, and an anti-inflammatory or anti-oxidative cosmetic composition or food composition.

A method for producing a polythiol compound, the method including reacting a halide represented by Formula (1) with an alkali metal compound selected from the group made of an alkali metal sulfide and an alkali metal hydroxide to obtain a polyol compound selected from the group made of a polyol compound represented by Formula (2) and a polyol compound represented by Formula (3), in which a content of iron in the alkali metal compound is 100 ppm or less on a mass basis.

##STR00001##

in Formula (1), X represents a halogen atom.

##STR00002##

A method for producing a polythiol compound, the method including reacting a halide represented by Formula (1) with an alkali metal compound selected from the group made of an alkali metal sulfide and an alkali metal hydroxide to obtain a polyol compound selected from the group made of a polyol compound represented by Formula (2) and a polyol compound represented by Formula (3), in which a content of iron in the alkali metal compound is 100 ppm or less on a mass basis.

##STR00001##

in Formula (1), X represents a halogen atom.

##STR00002##

The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

Provided is a method for producing a polythiol compound, including obtaining one or more polythiol compounds selected from the group consisting of a polythiol compound represented by Formula (3), a polythiol compound represented by Formula (4), and a polythiol compound represented by Formula (5) through steps including: reacting 2-mercaptoethanol with an epihalohydrin in an amount of 1.00 equivalent or more and 1.25 equivalent or less with respect to the 2-mercaptoethanol to obtain a polyol compound represented by Formula (1); and reacting the polyol compound represented by Formula (1) with an alkali metal sulfide in an amount of 1.04 equivalent or more and 1.25 equivalent or less with respect to the 2-mercaptoethanol to obtain a polyol compound represented by Formula (2). ##STR00001##
[in Formula (1), X represents a halogen atom] ##STR00002##

Provided is a method for producing a polythiol compound, including obtaining one or more polythiol compounds selected from the group consisting of a polythiol compound represented by Formula (3), a polythiol compound represented by Formula (4), and a polythiol compound represented by Formula (5) through steps including: reacting 2-mercaptoethanol with an epihalohydrin in an amount of 1.00 equivalent or more and 1.25 equivalent or less with respect to the 2-mercaptoethanol to obtain a polyol compound represented by Formula (1); and reacting the polyol compound represented by Formula (1) with an alkali metal sulfide in an amount of 1.04 equivalent or more and 1.25 equivalent or less with respect to the 2-mercaptoethanol to obtain a polyol compound represented by Formula (2). ##STR00001##
[in Formula (1), X represents a halogen atom] ##STR00002##

Disclosed is a limonene-sulfur polysulfide and methods for preparing the same. The polysulfide prepared according to these methods is flexible, moldable and otherwise capable of being formed in any manner consistent with a thermoplastic polymer. The limonene-sulfur polysulfide has been demonstrated to sequester inorganic palladium and inorganic mercury dissolved in water.