The present invention relates to an industrial process for the preparation of (5S,10S)-10-benzyl-16-methyl-11,14,18-trioxo-15,17,19-trioxa-2,7,8-trithia-12-azahenicosan-5-aminium (E)-3-carboxyacrylate salt of following formula (I): wherein X is fumarate. This process comprises the following successive key steps: a kinetic resolution, formation of disulfide compound, peptide coupling, and anion exchange reaction to obtain the desired product of formula (I). ##STR00001##

The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

The invention relates to a process for treating keratin fibres, in particular human keratin fibres such as the hair, comprising: (i) a step of applying a compound (I)

##STR00001##

and also the acid or base salts thereof, the optical or geometrical isomers thereof,
and the solvates thereof such as hydrates,
in which compound of formula (I): R.sup.1, R.sup.2, R.sup.3, R.sup.4, x, m, n, X.sup., are as defined in the description; (ii) a step of heating the keratin fibres to a temperature of at least 100 C., preferably ranging from 100 to 250 C.;
it is understood that steps (i) and (ii) may be performed at the same time or separately.

The process makes it possible to obtain good hair-conditioning cosmetic properties, with a long-lasting effect.

The invention also relates to the novel compounds and to a cosmetic composition comprising such a compound.

The invention relates to a process for treating keratin fibres, in particular human keratin fibres such as the hair, comprising: (i) a step of applying a compound (I)

##STR00001##

and also the acid or base salts thereof, the optical or geometrical isomers thereof,
and the solvates thereof such as hydrates,
in which compound of formula (I): R.sup.1, R.sup.2, R.sup.3, R.sup.4, x, m, n, X.sup., are as defined in the description; (ii) a step of heating the keratin fibres to a temperature of at least 100 C., preferably ranging from 100 to 250 C.;
it is understood that steps (i) and (ii) may be performed at the same time or separately.

The process makes it possible to obtain good hair-conditioning cosmetic properties, with a long-lasting effect.

The invention also relates to the novel compounds and to a cosmetic composition comprising such a compound.

The present invention relates to a novel compound exhibiting anti-oxidative or anti-inflammatory activity, a method of preparing the compound, a pharmaceutical composition for preventing or treating inflammatory diseases or the diseases caused by oxidation, which comprises the compound or a salt thereof as an active ingredient, and an anti-inflammatory or anti-oxidative cosmetic composition or food composition.

The present invention relates to a novel compound exhibiting anti-oxidative or anti-inflammatory activity, a method of preparing the compound, a pharmaceutical composition for preventing or treating inflammatory diseases or the diseases caused by oxidation, which comprises the compound or a salt thereof as an active ingredient, and an anti-inflammatory or anti-oxidative cosmetic composition or food composition.

The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3-dithiodipropionic acid (DPDPA) and N-ethyl-N-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.

The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3-dithiodipropionic acid (DPDPA) and N-ethyl-N-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.

The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3-dithiodipropionic acid (DPDPA) and N-ethyl-N-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.