There are disclosed phenethylamine compounds, the use of such compounds in the treatment of diseases associated with a serotonin 5-HT.sub.2 receptor, pharmaceutical compositions such as tablet compositions and kits containing the compounds, methods of delivering the compounds in a mist via inhalation, and methods of treating diseases or disorders associated with a serotonin 5-HT.sub.2 receptor, such as central nervous system (CNS) disorders or psychological disorders with the disclosed compounds.

The present invention provides a polysubstituted selenium-containing cyclopent(hex)ene skeleton derivative and a synthesis method thereof. The polysubstituted selenium-containing cyclopent(hex)ene skeleton derivative is prepared by a one-pot method using an arylacetylene compound and an unsaturated selenide reagent as reaction materials, in the presence of a free radical initiator. The synthesis method of the present invention is simple and efficient, requires no metal catalyst, has mild reaction conditions, and has good functional group tolerance and broad substrate scope. Moreover, cyclopent(hex)ene compounds with different substituents are widely present in active drug molecules, and selenium-containing compounds also have good biological activity against tumors, oxidation, inflammation, bacteria, viruses and others. Therefore, a complex selenide-containing cyclopent(hex)ene skeleton derivative is obtained starting from a simple substrate by the synthesis method of the present invention by constructing a CSe bond through a simple, efficient and sustainable strategy. The present invention has broad application prospects.

The present invention provides a polysubstituted selenium-containing cyclopent(hex)ene skeleton derivative and a synthesis method thereof. The polysubstituted selenium-containing cyclopent(hex)ene skeleton derivative is prepared by a one-pot method using an arylacetylene compound and an unsaturated selenide reagent as reaction materials, in the presence of a free radical initiator. The synthesis method of the present invention is simple and efficient, requires no metal catalyst, has mild reaction conditions, and has good functional group tolerance and broad substrate scope. Moreover, cyclopent(hex)ene compounds with different substituents are widely present in active drug molecules, and selenium-containing compounds also have good biological activity against tumors, oxidation, inflammation, bacteria, viruses and others. Therefore, a complex selenide-containing cyclopent(hex)ene skeleton derivative is obtained starting from a simple substrate by the synthesis method of the present invention by constructing a CSe bond through a simple, efficient and sustainable strategy. The present invention has broad application prospects.

A method of treating includes contacting cancer cells with a bis-(organoselanyl urea)aryl agent of Formula (I). The method includes effective inhibition of growth of cancer cells using the bis-(organoselanyl urea)aryl agent of Formula (I) as compared to doxorubicin ##STR00001##

A method of treating includes contacting cancer cells with a bis-(organoselanyl urea)aryl agent of Formula (I). The method includes effective inhibition of growth of cancer cells using the bis-(organoselanyl urea)aryl agent of Formula (I) as compared to doxorubicin ##STR00001##

A method of treating cancer including administering a bis-(organoselanyl urea)aryl agent having a Formula (I) to a subject with cancer. The method includes effective inhibition of growth of cancer cells using the compound of Formula (I) as compared to doxorubicin. ##STR00001##

A method of treating cancer including administering a bis-(organoselanyl urea)aryl agent having a Formula (I) to a subject with cancer. The method includes effective inhibition of growth of cancer cells using the compound of Formula (I) as compared to doxorubicin. ##STR00001##