The present invention relates to a compound having formula (I) below or a pharmaceutically acceptable salt thereof: ##STR00001## wherein: X is COOH or NH.sub.2; R is a straight or branched C.sub.1-C.sub.10 alkylene chain; and R.sub.1 is H, straight or branched C.sub.1-C.sub.10 alkyl, aryl, or R.sub.2CO wherein R.sub.2 is straight or branched C.sub.1-C.sub.10 alkyl, for use as antitumoral agents.

The present invention relates to a compound having formula (I) below or a pharmaceutically acceptable salt thereof: ##STR00001## wherein: X is COOH or NH.sub.2; R is a straight or branched C.sub.1-C.sub.10 alkylene chain; and R.sub.1 is H, straight or branched C.sub.1-C.sub.10 alkyl, aryl, or R.sub.2CO wherein R.sub.2 is straight or branched C.sub.1-C.sub.10 alkyl, for use as antitumoral agents.

Compounds of the formula 1 ##STR00001##
wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, are useful intermediates in the synthesis of fragrance ingredients such as Ambrox 2 ##STR00002##

Compounds of the formula 1 ##STR00001##
wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, are useful intermediates in the synthesis of fragrance ingredients such as Ambrox 2 ##STR00002##

The retinoid X receptors (RXRs) are ligand-activated transcription factors heterodimerize with a number of nuclear hormone receptors, thereby controlling a variety of physiological processes. The invention relates to novel enantiomer compounds which are derivatives of dihydroretinoic acid, their stereoselective synthesis, to pharmaceutical compositions containing the same and to the use of same in the treatment of diseases.

The retinoid X receptors (RXRs) are ligand-activated transcription factors heterodimerize with a number of nuclear hormone receptors, thereby controlling a variety of physiological processes. The invention relates to novel enantiomer compounds which are derivatives of dihydroretinoic acid, their stereoselective synthesis, to pharmaceutical compositions containing the same and to the use of same in the treatment of diseases.

Disclosed is a process for preparing unsaturated malonates and/or their isomers. The process includes the step of reacting an aldehyde and a dialkyl malonate in the presence of a Lewis acid and a carboxylic acid thereby forming an unsaturated malonate.

Disclosed is a process for preparing unsaturated malonates and/or their isomers. The process includes the step of reacting an aldehyde and a dialkyl malonate in the presence of a Lewis acid and a carboxylic acid thereby forming an unsaturated malonate.

The present disclosure provides esters of a retinoid and bakuchiol, such as esters of Formula (I). The present disclosure also provides compositions and kits comprising the esters, methods of producing the esters, methods of using the esters (e.g., for treating or preventing a skin disease, slowing the ageing of the skin, improving the appearance of the skin, or modulating a retinoid receptor).

##STR00001##

The present disclosure provides esters of a retinoid and bakuchiol, such as esters of Formula (I). The present disclosure also provides compositions and kits comprising the esters, methods of producing the esters, methods of using the esters (e.g., for treating or preventing a skin disease, slowing the ageing of the skin, improving the appearance of the skin, or modulating a retinoid receptor).

##STR00001##