Process for preparing a powdery organic peroxide formulation, said process comprises the following steps: a) preparing a reaction mixture comprising: 40-80 wt % water 10-25 wt % of an acid chloride or chloroformate, 1-4 wt % hydrogen peroxide, 2-8 wt % alkali metal hydroxide, 1-25 wt % of a phlegmatizer selected from the group consisting of ethylene glycol dibenzoate, phenyl benzoate, trimethylol propane tribenzoate, glyceryl tribenzoate, ethylene glycol ditoluate, 1,3-propanediol ditoluate, ethylene glycol 4-tert-butylbenzoate, ethylene glycol monobenzoate monotoluate, 2,3-butanediol dibenzoate, 4-methylphenyl benzoate acid ester, trimethylolpropane dibenzoate, and combinations thereof 0.002-0.20 wt % of a surfactant, and 0.25-5.0 wt % of an inert organic solvent, all percentages based on the weight of the reaction mixture, b) heating the reaction mixture at a temperature in the range 5-50 C.

Process for preparing a powdery organic peroxide formulation, said process comprises the following steps: a) preparing a reaction mixture comprising: 40-80 wt % water 10-25 wt % of an acid chloride or chloroformate, 1-4 wt % hydrogen peroxide, 2-8 wt % alkali metal hydroxide, 1-25 wt % of a phlegmatizer selected from the group consisting of ethylene glycol dibenzoate, phenyl benzoate, trimethylol propane tribenzoate, glyceryl tribenzoate, ethylene glycol ditoluate, 1,3-propanediol ditoluate, ethylene glycol 4-tert-butylbenzoate, ethylene glycol monobenzoate monotoluate, 2,3-butanediol dibenzoate, 4-methylphenyl benzoate acid ester, trimethylolpropane dibenzoate, and combinations thereof 0.002-0.20 wt % of a surfactant, and 0.25-5.0 wt % of an inert organic solvent, all percentages based on the weight of the reaction mixture, b) heating the reaction mixture at a temperature in the range 5-50 C.

A compound of general formula (I-1): ##STR00001## wherein the symbols are defined in the specification, has a selective S1P.sub.5 receptor binding activity and modulates the function of an S1P.sub.5 receptor, and can therefore be a therapeutic agent for a S1P.sub.5-mediated disease, for example, neurodegenerative diseases such as schizophrenia, Binswanger's disease and the like.

A compound of general formula (I-1): ##STR00001## wherein the symbols are defined in the specification, has a selective S1P.sub.5 receptor binding activity and modulates the function of an S1P.sub.5 receptor, and can therefore be a therapeutic agent for a S1P.sub.5-mediated disease, for example, neurodegenerative diseases such as schizophrenia, Binswanger's disease and the like.

A continuous flow production process for preparing organic peroxides directly from alcohols or alkanes takes very safe alcohols or alkanes as starting materials, and directly reacts to obtain designated peroxides. The production process is carried out in an integrated continuous flow reactor, and a safe starting source of alcohol or alkane is continuously added at the feed inlet of the integrated continuous flow reactor, and continuously provided with a designated peroxide at the discharge port of the integrated continuous flow reactor.

A continuous flow production process for preparing organic peroxides directly from alcohols or alkanes takes very safe alcohols or alkanes as starting materials, and directly reacts to obtain designated peroxides. The production process is carried out in an integrated continuous flow reactor, and a safe starting source of alcohol or alkane is continuously added at the feed inlet of the integrated continuous flow reactor, and continuously provided with a designated peroxide at the discharge port of the integrated continuous flow reactor.

The present invention concerns a method and an apparatus (10, 20) for a continuous preparation of organic peroxides, with the reactor comprising at least one flow channel (1, 1a, 1b) configured as a reaction zone; an inlet system (2) in fluid communication with a first end of the at least one flow channel and configured for introducing two or more substances or a combination of substances into the at least one flow channel; an outlet system (3) in fluid communication with a second end of the at least one flow channel, the second end being located downstream of the first end and the outlet system being configured for extracting a reaction product present at the second end; an oscillatory system (4, 5) configured for superimposing an oscillatory flow on the flow of substances passing through the at least one flow channel, the oscillatory being effected in at least a section of the at least one flow channel; and a controller configured to implement the method by controlling the inlet system to introduce, according to a first time characteristic, at least two substances or a combination of substances into the at least one flow channel, the oscillatory system to superimpose an oscillatory flow on at least a part of the flow of substances passing through the at least one flow channel, and the outlet system to extract, on an ongoing basis, the reaction product formed in the flow channel from the substances introduced such that the output mass flow rate corresponding to the sum of the input mass flow rates.

The present invention concerns a method and an apparatus (10, 20) for a continuous preparation of organic peroxides, with the reactor comprising at least one flow channel (1, 1a, 1b) configured as a reaction zone; an inlet system (2) in fluid communication with a first end of the at least one flow channel and configured for introducing two or more substances or a combination of substances into the at least one flow channel; an outlet system (3) in fluid communication with a second end of the at least one flow channel, the second end being located downstream of the first end and the outlet system being configured for extracting a reaction product present at the second end; an oscillatory system (4, 5) configured for superimposing an oscillatory flow on the flow of substances passing through the at least one flow channel, the oscillatory being effected in at least a section of the at least one flow channel; and a controller configured to implement the method by controlling the inlet system to introduce, according to a first time characteristic, at least two substances or a combination of substances into the at least one flow channel, the oscillatory system to superimpose an oscillatory flow on at least a part of the flow of substances passing through the at least one flow channel, and the outlet system to extract, on an ongoing basis, the reaction product formed in the flow channel from the substances introduced such that the output mass flow rate corresponding to the sum of the input mass flow rates.

Aqueous emulsion comprising: 25-70 wt % organic peroxide, based on the weight of the emulsion, a cyclohexane dicarboxylate ester, and water. This emulsion is storage stable and can be used for the production of polymers, in particular PVC, that come into contact with food products.

Aqueous emulsion comprising: 25-70 wt % organic peroxide, based on the weight of the emulsion, a cyclohexane dicarboxylate ester, and water. This emulsion is storage stable and can be used for the production of polymers, in particular PVC, that come into contact with food products.