The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof. ##STR00001##

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof. ##STR00001##

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

##STR00001##

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

##STR00001##

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

##STR00001##

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

##STR00001##

The present invention belongs to the field of pharmaceutical technology, and crystal forms of a 9-aminomethyl substituted tetracycline compound and a process for preparing the same. More specifically, the present invention relates to crystal forms of the compound represented by formula (1), a process for preparing crystal forms of the compound represented by formula (1) and use of said crystal forms in manufacture of medicament for treating and/or preventing an infection disease caused by tetracycline-sensitive bacteria and/or tetracycline-resistant bacteria. ##STR00001##

The present invention belongs to the field of pharmaceutical technology, and crystal forms of a 9-aminomethyl substituted tetracycline compound and a process for preparing the same. More specifically, the present invention relates to crystal forms of the compound represented by formula (1), a process for preparing crystal forms of the compound represented by formula (1) and use of said crystal forms in manufacture of medicament for treating and/or preventing an infection disease caused by tetracycline-sensitive bacteria and/or tetracycline-resistant bacteria. ##STR00001##

The ester compound of the present invention is represented by the following formula (1), wherein R.sup.1 to R.sup.24 are each independently a hydrogen atom, a halogen atom, a hydrocarbon group, or a hetero atom-containing hydrocarbon group; R.sup.1 to R.sup.10, R.sup.23, and R.sup.24 may be bonded to one another to form a ring or may form a multiple bond at which adjacent substituents are directly bonded; R.sup.11 to R.sup.24 may be bonded to one another to form a ring, or adjacent substituents may be bonded to one another to form a multiple bond; at least one set in R.sup.1 to R.sup.24 is bonded to one another to form a ring structure; n2 to n5 each independently represent an integer of 0 to 2; n1 and n6 each independently represent an integer of 0 or 1; and L.sup.1 and L.sup.2 are each independently a hydrocarbon group or a hetero atom-containing hydrocarbon group.

##STR00001##

The ester compound of the present invention is represented by the following formula (1), wherein R.sup.1 to R.sup.24 are each independently a hydrogen atom, a halogen atom, a hydrocarbon group, or a hetero atom-containing hydrocarbon group; R.sup.1 to R.sup.10, R.sup.23, and R.sup.24 may be bonded to one another to form a ring or may form a multiple bond at which adjacent substituents are directly bonded; R.sup.11 to R.sup.24 may be bonded to one another to form a ring, or adjacent substituents may be bonded to one another to form a multiple bond; at least one set in R.sup.1 to R.sup.24 is bonded to one another to form a ring structure; n2 to n5 each independently represent an integer of 0 to 2; n1 and n6 each independently represent an integer of 0 or 1; and L.sup.1 and L.sup.2 are each independently a hydrocarbon group or a hetero atom-containing hydrocarbon group.

##STR00001##