The invention provides bridged diindole compounds, related pharmaceutical compositions and methods of use thereof, for the prevention, palliation and/or treatment of nervous system disorders.

The invention provides bridged diindole compounds, related pharmaceutical compositions and methods of use thereof, for the prevention, palliation and/or treatment of nervous system disorders.

The present invention provides a curable composition containing a compound represented by General Formula A and a compound represented by General Formula B.

ArL-Sp-Pol).sub.n  (General Formula A)

In General Formula A, Ar represents an n-valent group containing a nitrogen-containing fused aromatic ring as a partial structure; L represents a linking group such as —O— and —C(═O)O—; Sp represents a single bond or a divalent linking group; Pol represents a hydrogen atom or a polymerizable group; n represents 1 or 2; and the compound represented by General Formula A has at least one polymerizable group.

##STR00001##

In General Formula B, R′, R″, and R′″ are each independently a hydrogen atom or a substituent; R′ and R″ or R″ and R′″ may be bonded to each other to form a ring that may have a substituent; and W is a hydrogen atom or a substituent. Using the curable composition of the present invention, it is possible to form a cured product having a small Abbe number, a large partial dispersion ratio, and high light stability.

A composition which comprises substance represented by Formula (I),

##STR00001##

[Meanings of the symbols that are included in the formula are given in the specification as definitions]

a pharmaceutically acceptable carrier, and a dissolution aid.is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.

A composition which comprises substance represented by Formula (I),

##STR00001##

[Meanings of the symbols that are included in the formula are given in the specification as definitions]

a pharmaceutically acceptable carrier, and a dissolution aid.is useful for improving solubility, oral absorbability and/or absorbability in blood of a poorly water-soluble or water insoluble tetracyclic compounds having an ALK inhibitory activity that are useful as a prophylactic and/or therapeutic agent for cancer, depression, and cognitive function disorder.

The present invention provides compositions, methods, and kits comprising one or more ROR inhibitors, alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g., prostate cancer, such as castration-resistant prostate cancer (CRPC), and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, lymphoma, and glioma.

The present invention provides compositions, methods, and kits comprising one or more ROR inhibitors, alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g., prostate cancer, such as castration-resistant prostate cancer (CRPC), and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, lymphoma, and glioma.

Provided is a compound of Chemical Formula 1:

##STR00001## wherein: Ar11 to Ar15 are each independently a substituted or unsubstituted aryl or heteroaryl group, or are bonded to an adjacent substituent to form a substituted or unsubstituted ring, L and L2 to L5 are each independently a direct bond or a substituted or unsubstituted arylene group, R1 is hydrogen, deuterium, a halogen group, a nitrile group, or a substituted or unsubstituted aryl or heteroaryl group, and is bonded to an adjacent substituent to form a substituted or unsubstituted ring, r1 is 0 to 8, and when r1 is 2 or more, the R1s are the same as or different from each other, and n is an integer from 1 to 3, and when n is 2 or 3, the Ls are the same as or different from each other,
and an organic light emitting diode comprising the same.

The invention provides novel compounds having the general formula (I)

##STR00001##

wherein R.sup.1, Y and R.sup.2 are as described herein, compositions including the compounds and methods of using the compounds.

The invention provides novel compounds having the general formula (I)

##STR00001##

wherein R.sup.1, Y and R.sup.2 are as described herein, compositions including the compounds and methods of using the compounds.