A subject of the present invention is the use of a compound having the general formula (I): (I) wherein V, W, X.sub.4, X.sub.5, X.sub.6, X.sub.7, X.sub.4, X.sub.5, X.sub.6, X.sub.7, Y, Y, R.sub.3, R.sub.3, R.sub.4 and R.sub.4 are as defined in any one of claims 1 to 11, for the detection, capture and/or separation of polluting gases, in particular those selected from the group comprising carbon dioxide, methane, sulfur dioxide, nitrogen oxides, carbon monoxide, linear hydrocarbons, linear mono-olefins and their mixtures, and preferably carbon dioxide. Another subject of the invention is a compound of formula (I) wherein V, W, X.sub.4, X.sub.5, X.sub.6, X.sub.7, X.sub.4, X.sub.5, X.sub.6, X.sub.7, Y, Y, R.sub.3, R.sub.3, R.sub.4 and R.sub.4 are as defined in any one of claims 12 to 21.

##STR00001##

The present invention provides compounds of Formula I: ##STR00001##
and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR and methods for their preparation and use.

The present invention provides compounds of Formula I: ##STR00001##
and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and methods of using these compounds to treat or prevent a disease or disorder mediated by FXR. Specifically, the present invention relates to isoxazole derivatives useful as agonists for FXR and methods for their preparation and use.

A chiral amine-squaramide compound based on a spirobiindane skeleton, a preparation method and use thereof provided. The chiral amine-squaramide is an enantiomeric compound having the general formula (I) and is useful for asymmetric catalytic organic reactions with good catalytic activity and enantioselectivity. The chiral amine-squaramide compound is obtained by preparation of compound of formula (I) through addition of a compound of formula (II) with squaric acid ester. The synthetic reaction route is simple, and it is easy for large-scale application. The novel chiral amine-squaramide organocatalyst has economic utility and promising industrial applications.

##STR00001##

A chiral amine-squaramide compound based on a spirobiindane skeleton, a preparation method and use thereof provided. The chiral amine-squaramide is an enantiomeric compound having the general formula (I) and is useful for asymmetric catalytic organic reactions with good catalytic activity and enantioselectivity. The chiral amine-squaramide compound is obtained by preparation of compound of formula (I) through addition of a compound of formula (II) with squaric acid ester. The synthetic reaction route is simple, and it is easy for large-scale application. The novel chiral amine-squaramide organocatalyst has economic utility and promising industrial applications.

##STR00001##

A compound having a structure of Formula I: ##STR00001##
is provided. In the structure of Formula I, each one of X.sup.1 to X.sup.16 is independently CR.sup.X or N; each R.sup.X and R are independently selected from the group consisting of hydrogen, deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, carbazole, azacarbazole, dibenzofuran, dibenzothiophene, dibenzoselenophene, azadibenzofuran, azadibenzothiophene, azadibenzoselenophene, triphenylene, azatriphenylene, and combinations thereof; and any adjacent R.sup.X can join to form fused or unfused rings. Formulations and devices, such as an OLEDs, that include the compound containing a structure of Formula I are also described.

A compound having a structure of Formula I: ##STR00001##
is provided. In the structure of Formula I, each one of X.sup.1 to X.sup.16 is independently CR.sup.X or N; each R.sup.X and R are independently selected from the group consisting of hydrogen, deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, carbazole, azacarbazole, dibenzofuran, dibenzothiophene, dibenzoselenophene, azadibenzofuran, azadibenzothiophene, azadibenzoselenophene, triphenylene, azatriphenylene, and combinations thereof; and any adjacent R.sup.X can join to form fused or unfused rings. Formulations and devices, such as an OLEDs, that include the compound containing a structure of Formula I are also described.

The present disclosure relates to an organic electroluminescent compound represented by formula 1 and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosure, an organic electroluminescent device having improved driving voltage and/or luminous efficiency characteristics can be provided.

The present disclosure relates to an organic electroluminescent compound represented by formula 1 and an organic electroluminescent device comprising the same. By comprising the organic electroluminescent compound of the present disclosure, an organic electroluminescent device having improved driving voltage and/or luminous efficiency characteristics can be provided.

A compound having a structure of Formula I:

##STR00001##

is provided. In the structure of Formula I, each one of X.sup.1 to X.sup.16 is independently CR.sup.X or N; each R.sup.X and R are independently selected from the group consisting of hydrogen, deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, carbazole, azacarbazole, dibenzofuran, dibenzothiophene, dibenzoselenophene, azadibenzofuran, azadibenzothiophene, azadibenzoselenophene, triphenylene, azatriphenylene, and combinations thereof; and any adjacent R.sup.X can join to form fused or unfused rings. Formulations and devices, such as an OLEDs, that include the compound containing a structure of Formula I are also described.