The present disclosure provides click-crosslinked hydrogels and methods of use.

Substituted pyridines that modulate HIF-2a activity, pharmaceutical compositions containing the substituted pyridines, and methods of using these chemical entities for treating proliferative diseases and conditions associated with HIF-2a activity are described herein.

Substituted pyridines that modulate HIF-2a activity, pharmaceutical compositions containing the substituted pyridines, and methods of using these chemical entities for treating proliferative diseases and conditions associated with HIF-2a activity are described herein.

A substituted trans-cycloheptene according to formula (I); wherein: a) Z and L are each selected from the group consisting of SiR.sup.1R.sup.2, CH.sub.2, CHOH, and CHR.sup.2; R.sup.1 is phenyl or CH.sub.3; R.sup.2 is phenyl, CH.sub.3, (CH.sub.2).sub.nCN, or (CH.sub.2).sub.nOH, wherein n is an integer from 1 to 5; R.sup.a and R.sup.b are each individually selected from the group consisting of H, OH, and CH.sub.3; and Z and L are not both SiR.sup.1R.sup.2; or b) Z is BocN, L is CH.sub.2, R.sup.a is H, and R.sup.b is H; or c) Z is C=0, L is CH.sub.2, R.sup.a is H, and R.sup.b is H. ##STR00001##

A substituted trans-cycloheptene according to formula (I); wherein: a) Z and L are each selected from the group consisting of SiR.sup.1R.sup.2, CH.sub.2, CHOH, and CHR.sup.2; R.sup.1 is phenyl or CH.sub.3; R.sup.2 is phenyl, CH.sub.3, (CH.sub.2).sub.nCN, or (CH.sub.2).sub.nOH, wherein n is an integer from 1 to 5; R.sup.a and R.sup.b are each individually selected from the group consisting of H, OH, and CH.sub.3; and Z and L are not both SiR.sup.1R.sup.2; or b) Z is BocN, L is CH.sub.2, R.sup.a is H, and R.sup.b is H; or c) Z is C=0, L is CH.sub.2, R.sup.a is H, and R.sup.b is H. ##STR00001##

The invention provides novel compounds having the general formula: ##STR00001##
wherein R.sup.1 to R.sup.6 are as described herein, compositions including the compounds and methods of using the compounds.

The invention provides novel compounds having the general formula: ##STR00001##
wherein R.sup.1 to R.sup.6 are as described herein, compositions including the compounds and methods of using the compounds.

The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

##STR00001##

The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

##STR00001##

Provided is a method for measuring tyrosine phosphatase and tyrosine kinase activity, as a high-sensitivity measuring method, which is suitable for high throughput and which uses a compound represented by general formula (I) (in the formula, A represents a conjugated ring; L represents a linker or the like having a labeling substance at an end; R.sup.1 represents a hydrogen atom or the like; and R.sup.2 and R.sup.3 each represent a hydrogen atom, an alkyl group or the like).