Patent classifications
C07D253/08
NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula XII:
##STR00001##
where R.sup.a, R.sup.b, R.sup.2, R.sup.7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
COMPOUND AND PREPARATION AND APPLICATION THEREOF
The present invention discloses a compound, which comprises the structure shown in FIG. 1; and further discloses a preparation method thereof, a precursor material used in the preparation method, explosives comprising the compound, and the application thereof in the field of explosives, in particular in the application of green environmentally-friendly primers. The compound disclosed by the invention may provide green environmental protection type primer, and meets the problem of requiring green environmental protection primers in many fields such as military industry, firework and civil explosion engineering. The compound disclosed in the invention has a simple preparation method and may be prepared by simple reaction steps and conditions, which has the advantages of being green and reliable as no pollution during the reaction process and use, no metal required in the compound structure, with good stability, high impact sensitivity, friction sensitivity, and initiation capability, and appropriate minimum initiating charge.
COMPOUND AND PREPARATION AND APPLICATION THEREOF
The present invention discloses a compound, which comprises the structure shown in FIG. 1; and further discloses a preparation method thereof, a precursor material used in the preparation method, explosives comprising the compound, and the application thereof in the field of explosives, in particular in the application of green environmentally-friendly primers. The compound disclosed by the invention may provide green environmental protection type primer, and meets the problem of requiring green environmental protection primers in many fields such as military industry, firework and civil explosion engineering. The compound disclosed in the invention has a simple preparation method and may be prepared by simple reaction steps and conditions, which has the advantages of being green and reliable as no pollution during the reaction process and use, no metal required in the compound structure, with good stability, high impact sensitivity, friction sensitivity, and initiation capability, and appropriate minimum initiating charge.
ORGANIC COMPOUND, ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DEVICE INCLUDING THE COMPOUND
The present disclosure relates to an organic compound having the following structure of Chemical Formula 1, and an organic light emitting diode (OLED) and an organic light emitting device including the organic compound. The organic compound includes a triazine moiety of an electron acceptor and a fused hetero aromatic moiety of an electron donor separated from the triazine moiety. The organic compound includes the electron acceptor moiety and the electron donor moiety in a single molecule, thus charges can be moved in the molecule. Also, since the organic compound includes the rigid fused hetero aromatic ring, three dimensional conformation of the organic compound is limited, and therefore the compound may have excellent luminous efficiency and color purity.
##STR00001##
ORGANIC COMPOUND, ORGANIC LIGHT EMITTING DIODE AND ORGANIC LIGHT EMITTING DEVICE INCLUDING THE COMPOUND
The present disclosure relates to an organic compound having the following structure of Chemical Formula 1, and an organic light emitting diode (OLED) and an organic light emitting device including the organic compound. The organic compound includes a triazine moiety of an electron acceptor and a fused hetero aromatic moiety of an electron donor separated from the triazine moiety. The organic compound includes the electron acceptor moiety and the electron donor moiety in a single molecule, thus charges can be moved in the molecule. Also, since the organic compound includes the rigid fused hetero aromatic ring, three dimensional conformation of the organic compound is limited, and therefore the compound may have excellent luminous efficiency and color purity.
##STR00001##
SUBSTITUTED BENZAZINONES AS ANTIBACTERIAL COMPOUNDS
The present invention relates to LpxC antibacterial compounds of Formula (IA):
##STR00001##
corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation, treatment methods and uses for bacterial infections, especially those caused by gram-negative bacteria.
SUBSTITUTED BENZAZINONES AS ANTIBACTERIAL COMPOUNDS
The present invention relates to LpxC antibacterial compounds of Formula (IA):
##STR00001##
corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation, treatment methods and uses for bacterial infections, especially those caused by gram-negative bacteria.
Probes for imaging huntingtin protein
- Celia Dominguez ,
- John Wityak ,
- Jonathan Bard ,
- Christopher John Brown ,
- Michael Edward Prime ,
- Derek Alexander Weddell ,
- Daryl Simon WALTER ,
- Paul Richard GILES ,
- Ian James Wigginton ,
- Malcolm George Taylor ,
- Sébastien René Gabriel GALAN ,
- Peter David Johnson ,
- Thomas Martin KRÜLLE ,
- Inaki Morao ,
- Daniel Clark-Frew
Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use. ##STR00001##
Probes for imaging huntingtin protein
- Celia Dominguez ,
- John Wityak ,
- Jonathan Bard ,
- Christopher John Brown ,
- Michael Edward Prime ,
- Derek Alexander Weddell ,
- Daryl Simon WALTER ,
- Paul Richard GILES ,
- Ian James Wigginton ,
- Malcolm George Taylor ,
- Sébastien René Gabriel GALAN ,
- Peter David Johnson ,
- Thomas Martin KRÜLLE ,
- Inaki Morao ,
- Daniel Clark-Frew
Provided are imaging agents comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use. ##STR00001##
Neprilysin inhibitors
In one aspect, the invention relates to compounds having the formula XII: ##STR00001##
where R.sup.a, R.sup.b, R.sup.2, R.sup.7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.