C07D255/02

FBSA-based therapeutic and radioimaging conjugates targeting carbonic anhydrase positive cancers

The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of carbonic anhydrase IX inhibitors. The present disclosure also relates to the use of targeting conjugates of carbonic anhydrase IX inhibitors in methods of treating disease and for imaging of disease.

PSMA-targeting compounds and uses thereof

Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

PSMA-targeting compounds and uses thereof

Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.

Terbium and dysprosium complexes with optimised antenna, used as luminescent markers

The present technology relates to luminescent lanthanide complexes comprising a chelating agent, formed of a macrocycle or ligand, complexing a lanthanide ion Ln.sup.3+ selected from terbium and dysprosium, the chelating agent comprising at least one group of the structure (B) below; and a process for detecting a biomolecule using said lanthanide complex comprising coupling a luminescent lanthanide complex of the present technology having a reactive group with said biomolecule. ##STR00001##

SPIROUREA DERIVATIVES

The invention relates to compounds of Formula (I)

##STR00001##

wherein X.sup.1, X.sup.2, X.sup.3, Y, R.sup.1, R.sup.2A, R.sup.2B, R.sup.3, and R.sup.4 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.

SPIROUREA DERIVATIVES

The invention relates to compounds of Formula (I)

##STR00001##

wherein X.sup.1, X.sup.2, X.sup.3, Y, R.sup.1, R.sup.2A, R.sup.2B, R.sup.3, and R.sup.4 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.

4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION

Benzoylamides of the general formula (I) are described as herbicides.

##STR00001##

In this formula (I), X, R and R.sup.a represent radicals such as alkyl, cycloalkyl and halogen. Q represents a five-membered heterocycle.

4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION

Benzoylamides of the general formula (I) are described as herbicides.

##STR00001##

In this formula (I), X, R and R.sup.a represent radicals such as alkyl, cycloalkyl and halogen. Q represents a five-membered heterocycle.

Coating Composition Comprising an Alkyd-Comprising Resin and a Drier

A coating composition comprising an alkyd-comprising resin and a drier comprising a dinudear ligand-manganese complex comprising manganese and a 1,4,7-trisubstituted-1,4,7-triazacyclononane ligand, wherein the alkyd-comprising resin is an alkyd-stabilized non-aqueous dispersion of particles of addition polymer in a non-aqueous liquid phase comprising alkyd.

Amphiphilic derivatives of triazamacrocyclic compounds, products and compositions including same, and synthesis methods and uses thereof

The invention relates to amphiphilic derivatives of a triazamacrocyclic compound, as well as to said derivatives as active molecule transporters. The invention also relates to a nanodrug including at least one amphiphilic derivative of a triazamacrocyclic compound and at least one active molecule of a protein such as an antibody, in particular for the treatment of autoimmune diseases or for the treatment of cancer.