Patent classifications
C07D273/02
OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF
The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.
NOVEL SOLID STATE FORMS OF INDOXACARB
The present disclosure relates to solid state forms of Indoxacarb or its solvate, processes for preparation thereof and agrochemical compositions thereof.
NOVEL SOLID STATE FORMS OF INDOXACARB
The present disclosure relates to solid state forms of Indoxacarb or its solvate, processes for preparation thereof and agrochemical compositions thereof.
HETEROCYCLIC GLP-1R AGONISTS
Disclosed herein are heterocyclic compounds that activate GLP-1R pathways. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the GLP-1R agonists are disclosed, alone or in combination with other therapeutic agents, for the treatment of diabetes, obesity, and other diseases or conditions dependent on GLP-1R pathways.
Macrocyclic compounds as proteasome inhibitors
The compounds of the present invention are represented by the following compounds having Formula I and Formula (I): ##STR00001##
where the substituents R.sup.1, R.sup.2, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R, R, X, Y, and Z are as defined herein and ##STR00002##
where the substituents R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R, R, X, Y, and Z are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.