The present invention relates to synthetic methods for 1,2,4-oxadiazole compounds. The general synthetic scheme is: ##STR00001##
R.sub.1 represents ?CH.sub.2O.sup.tBu or ?CH(CH.sub.3)O.sup.tBu, R.sub.3 represents ?CH.sub.2C(O)NHCPh.sub.3, ?CH.sub.2CH.sub.2C(O)NHCPh.sub.3, ?CH.sub.2C(O)O.sup.tBu, or ?CH.sub.2CH.sub.2C(O)O.sup.tBu, and Aaa is an amino acid residue selected from Thr and Ser; wherein the C-terminus thereof is esterified, and wherein the hydroxy moiety of the side chain of Thr or Ser is substituted with tbutyl; the base is triethylamine; and the solvent is tetrahydrofuran.

The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as conjugated lipomers or lipomers) containing one or more groups of the formula (iii): ##STR00001##
wherein R.sup.3 and R.sup.4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.

The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as conjugated lipomers or lipomers) containing one or more groups of the formula (iii): ##STR00001##
wherein R.sup.3 and R.sup.4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.

The present invention relates to synthetic methods for 1,2,4-oxadiazole compounds. The general synthetic scheme is:

##STR00001##

R.sub.1 substituents generally are optionally substituted methanol or ethanol moieties, R.sub.3 substituents generally are optionally substituted acetic or propanoic acids or their amides and Aaa is Thr or Ser which has a free, amidated or esterified C-terminus.

The present invention relates to pharmaceutical compositions of 1,2,4-oxadiazole compounds or a pharmaceutically acceptable salt thereof of formula (I)

##STR00001##

In the formula Q is O, R.sub.1 is the side chain of Ser, R.sub.2 is CO-Thr, R.sub.3 is the side chain of Asn or Glu, and R.sub.4, R.sub.5 and R.sub.6 are each H.

The present invention relates to pharmaceutical compositions of 1,2,4-oxadiazole compounds or a pharmaceutically acceptable salt thereof of formula (I)

##STR00001##

In the formula Q is O, R.sub.1 is the side chain of Ser, R.sub.2 is CO-Thr, R.sub.3 is the side chain of Asn or Glu, and R.sub.4, R.sub.5 and R.sub.6 are each H.

The invention provides a BAF complex modulating compound for use as a coronavirus antiviral; wherein the BAF complex modulating compound is of Formula (I): ##STR00001##

The invention provides a BAF complex modulating compound for use as a coronavirus antiviral; wherein the BAF complex modulating compound is of Formula (I): ##STR00001##

The present invention relates to 1,2,4-oxadiazole and 1,2,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signaling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.

A polyester film including a cyclic carbodiimide compound represented by the following Formula (O-1) has good film thickness uniformity without increase in viscosity. R.sup.1 and R.sup.5 represent an alkyl group, an aryl group, or an alkoxy group; R.sup.2 to R.sup.4 and R.sup.6 to R.sup.8 represent a hydrogen atom, an alkyl group, an aryl group, or an alkoxy group; X.sup.1 and X.sup.2 represent a single bond, O, CO, S, SO.sub.2, NH, or CH.sub.2; and L.sup.1 represents a divalent linking group. ##STR00001##