Patent classifications
C07D281/02
Benzothiazepine compounds and their use as bile acid modulators
The invention relates to 1,5-benzothiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.
NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS
The present invention provides a compound having the structure:
##STR00001##
or a pharmaceutically acceptable salt or ester thereof.
NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS
The present invention provides a compound having the structure:
##STR00001##
or a pharmaceutically acceptable salt or ester thereof.
2-HOMOPIPERAZINE-1-YL-4H-1,3-BENZOTHIAZINE-4-ONE DERIVATIVES AND PROCESS FOR THE PREPARATION OF 2- (HOMO)PIPERAZINE 1,3-BENZOTHIAZINE-4-ONE HYDROCHLORIDES
2-homopiperazine-1-yl-4H,1,3-bensothiazine-4-one derivatives of formula (I) are provided. They are usehil in the treatment of bacterial infections, in particular tuberculosis, buruli ulcer and leprosy. A process for the preparation of 2-(homo)piperazine 1, 3-benzothiazine-4-one hydrochlorides is also provided.
2-HOMOPIPERAZINE-1-YL-4H-1,3-BENZOTHIAZINE-4-ONE DERIVATIVES AND PROCESS FOR THE PREPARATION OF 2- (HOMO)PIPERAZINE 1,3-BENZOTHIAZINE-4-ONE HYDROCHLORIDES
2-homopiperazine-1-yl-4H,1,3-bensothiazine-4-one derivatives of formula (I) are provided. They are usehil in the treatment of bacterial infections, in particular tuberculosis, buruli ulcer and leprosy. A process for the preparation of 2-(homo)piperazine 1, 3-benzothiazine-4-one hydrochlorides is also provided.
CARBOXYLIC DIARYLTHIAZEPINEAMINES AS MU-OPIOID RECEPTOR AGONISTS
The present invention provides a compound having the structure of the instant invention of a pharmaceutically acceptable salt or ester thereof, methods of preparing the same, and methods of treating a subject with compounds of the instant invention in combination therapies.
Class of mu-opioid receptor agonists
The present invention provides a compound having the structure: ##STR00001##
or a pharmaceutically acceptable salt or ester thereof.
Class of mu-opioid receptor agonists
The present invention provides a compound having the structure: ##STR00001##
or a pharmaceutically acceptable salt or ester thereof.
NRF2 Regulators
The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
NRF2 Regulators
The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.