The disclosure pertains to chemical entities such as a compound or a pharmaceutically acceptable salt that inhibit inflammatory responses by, for example, inhibiting the oligomerization of Apoptosis-associated speck-like protein containing a C-terminal caspase-recruitment domain (ASC). Also provided are methods of treating various disease states using compounds that inhibit oligomerization of ASC protein.

A compound represented by general formula (1) or a pharmacologically acceptable salt thereof for inhibiting 15-PDGH.

A compound represented by general formula (1) or a pharmacologically acceptable salt thereof for inhibiting 15-PDGH.