Patent classifications
C07D285/38
Electronically activated strained alkynes
Compounds of Formula I: ##STR00001## wherein: R.sup.1 and R.sup.2 are hydrogen or C.sub.1 to C.sub.12 linear or branched alkyl; R.sup.3 is hydrogen, C.sub.1 to C.sub.12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R.sup.4 is absent; and when X is nitrogen, R.sup.4 is C.sub.1 to C.sub.12 linear or branched alkyl or nitrogen protecting groups. The compounds are useful as reagents in 1,3-cycloaddition reactions.
Electronically activated strained alkynes
Compounds of Formula I: ##STR00001## wherein: R.sup.1 and R.sup.2 are hydrogen or C.sub.1 to C.sub.12 linear or branched alkyl; R.sup.3 is hydrogen, C.sub.1 to C.sub.12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R.sup.4 is absent; and when X is nitrogen, R.sup.4 is C.sub.1 to C.sub.12 linear or branched alkyl or nitrogen protecting groups. The compounds are useful as reagents in 1,3-cycloaddition reactions.
ELECTRONICALLY ACTIVATED STRAINED ALKYNES
Compounds of Formula I:
##STR00001## wherein: R.sup.1 and R.sup.2 are hydrogen or C.sub.1 to C.sub.12 linear or branched alkyl; R.sup.3 is hydrogen, C.sub.1 to C.sub.12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R.sup.4 is absent; and when X is nitrogen, R.sup.4 is C.sub.1 to C.sub.12 linear or branched alkyl or nitrogen protecting groups. The compounds are useful as reagents in 1,3-cycloaddition reactions.
ELECTRONICALLY ACTIVATED STRAINED ALKYNES
Compounds of Formula I:
##STR00001## wherein: R.sup.1 and R.sup.2 are hydrogen or C.sub.1 to C.sub.12 linear or branched alkyl; R.sup.3 is hydrogen, C.sub.1 to C.sub.12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R.sup.4 is absent; and when X is nitrogen, R.sup.4 is C.sub.1 to C.sub.12 linear or branched alkyl or nitrogen protecting groups. The compounds are useful as reagents in 1,3-cycloaddition reactions.
METHODS, COMPOUNDS, COMPOSITIONS AND VEHICLES FOR DELIVERING 3-AMINO-1-PROPANESULFONIC ACID
The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compound that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to the prevention and treatment of Alzheimer's disease