The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to, the prevention and treatment of Alzheimer's disease.

Compounds of Formula I:

##STR00001## wherein: R.sup.1 and R.sup.1 are independently selected from hydrogen, halogen, C.sub.1-to-C.sub.12 linear or branched hydroxyalkyl, C.sub.1-to-C.sub.12 linear or branched halo-alkyl, carboxy, carboxyalkyl, amido, N-alkylamido, N,N-dialkylamido, carbamoyloxy, N-alkylcarbamoyloxy, and N,N-dialkylcarbamoyloxy, provided that that R.sup.1 and R.sup.1 are not simultaneously hydrogen; R.sup.2 and R.sup.2 hydrogen, halogen, C.sub.1-to-C.sub.12 linear or branched hydroxyalkyl, C.sub.1-to-C.sub.12 linear or branched halo-alkyl, carboxy, carboxyalkyl, amido, N-alkylamido, N,N-dialkylamido, carbamoyloxy, N-alkylcarbamoyloxy, and N,N-dialkylcarbamoyloxy, provided that that R.sup.2 and R.sup.2 are not simultaneously hydrogen; R.sup.3 is selected from hydrogen, C.sub.1to C.sub.12 linear or branched alkyl, and nitrogen protecting groups; X is oxygen or nitrogen; when X is oxygen, R.sup.4 is absent; and when X is nitrogen, R.sup.4 is selected from H, C.sub.1-to-C.sub.12 linear or branched alkyl, and nitrogen protecting groups.

Compounds of Formula I:

##STR00001## wherein: R.sup.1 and R.sup.1 are independently selected from hydrogen, halogen, C.sub.1-to-C.sub.12 linear or branched hydroxyalkyl, C.sub.1-to-C.sub.12 linear or branched halo-alkyl, carboxy, carboxyalkyl, amido, N-alkylamido, N,N-dialkylamido, carbamoyloxy, N-alkylcarbamoyloxy, and N,N-dialkylcarbamoyloxy, provided that that R.sup.1 and R.sup.1 are not simultaneously hydrogen; R.sup.2 and R.sup.2 hydrogen, halogen, C.sub.1-to-C.sub.12 linear or branched hydroxyalkyl, C.sub.1-to-C.sub.12 linear or branched halo-alkyl, carboxy, carboxyalkyl, amido, N-alkylamido, N,N-dialkylamido, carbamoyloxy, N-alkylcarbamoyloxy, and N,N-dialkylcarbamoyloxy, provided that that R.sup.2 and R.sup.2 are not simultaneously hydrogen; R.sup.3 is selected from hydrogen, C.sub.1to C.sub.12 linear or branched alkyl, and nitrogen protecting groups; X is oxygen or nitrogen; when X is oxygen, R.sup.4 is absent; and when X is nitrogen, R.sup.4 is selected from H, C.sub.1-to-C.sub.12 linear or branched alkyl, and nitrogen protecting groups.

The present invention relates to a polymerizable composition comprising at least one ethylenically unsaturated, polymerizable compound and at least one oxime sulfonate compound of the formula I

QA.sub.aB.sub.bC.sub.c(I)

where a is 0, 1, 2, 3, 4 or 6, b is 0, 1, 2, 3, 4 or 6, and c is 0, 1, 2, 3, 4 or 6, where the sum of a+b+c is 1, 2, 3, 4 or 6
where
A is a group

##STR00001##

B is a group

##STR00002##

C is a group

##STR00003##

where # denotes the point of attachment to Q; X is S or NR.sup.14 and Q, R.sup.1, R.sup.2, R.sup.3 and R.sup.14 are as defined in claim 1 and in the description.

The present invention also relates to the use of the this composition, to novel oxime sulfonates and the use of the oxime sulfonates as thermal curing promoter.

The present invention relates to a polymerizable composition comprising at least one ethylenically unsaturated, polymerizable compound and at least one oxime sulfonate compound of the formula I

QA.sub.aB.sub.bC.sub.c(I)

where a is 0, 1, 2, 3, 4 or 6, b is 0, 1, 2, 3, 4 or 6, and c is 0, 1, 2, 3, 4 or 6, where the sum of a+b+c is 1, 2, 3, 4 or 6
where
A is a group

##STR00001##

B is a group

##STR00002##

C is a group

##STR00003##

where # denotes the point of attachment to Q; X is S or NR.sup.14 and Q, R.sup.1, R.sup.2, R.sup.3 and R.sup.14 are as defined in claim 1 and in the description.

The present invention also relates to the use of the this composition, to novel oxime sulfonates and the use of the oxime sulfonates as thermal curing promoter.

Compounds of Formula I: ##STR00001## wherein: R.sup.1 and R.sup.2 are hydrogen or C.sub.1 to C.sub.12 linear or branched alkyl; R.sup.3 is hydrogen, C.sub.1 to C.sub.12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R.sup.4 is absent; and when X is nitrogen, R.sup.4 is C.sub.1 to C.sub.12 linear or branched alkyl or nitrogen protecting groups. The compounds are useful as reagents in 1,3-cycloaddition reactions.

Compounds of Formula I: ##STR00001## wherein: R.sup.1 and R.sup.2 are hydrogen or C.sub.1 to C.sub.12 linear or branched alkyl; R.sup.3 is hydrogen, C.sub.1 to C.sub.12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R.sup.4 is absent; and when X is nitrogen, R.sup.4 is C.sub.1 to C.sub.12 linear or branched alkyl or nitrogen protecting groups. The compounds are useful as reagents in 1,3-cycloaddition reactions.

A radiation-sensitive resin composition includes a first polymer including a first structural unit that includes a first acid-labile group; a radiation-sensitive acid generator; and a compound represented by formula (1). n is 1 or 2. R.sup.1 represents a hydrogen atom or a monovalent organic group having 1 to 20 carbon atoms in a case in which n is 1. R.sup.1 represents a divalent organic group having 1 to 20 carbon atoms in a case in which n is 2. R.sup.2 represents a hydrogen atom or a monovalent organic group having 1 to 20 carbon atoms. E represents a group represented by formula (i). R.sup.2 and E may taken together represent a ring structure having 3 to 20 ring atoms together with the nitrogen atom. X represents a divalent organic group having 1 to 20 carbon atoms. R.sup.3 represents a second acid-labile group.

##STR00001##

Compounds of Formula I:

##STR00001## wherein: R.sup.1 and R.sup.2 are hydrogen or C.sub.1 to C.sub.12 linear or branched alkyl; R.sup.3 is hydrogen, C.sub.1 to C.sub.12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R.sup.4 is absent; and when X is nitrogen, R.sup.4 is C.sub.1 to C.sub.12 linear or branched alkyl or nitrogen protecting groups. The compounds are useful as reagents in 1,3-cycloaddition reactions.

Compounds of Formula I:

##STR00001## wherein: R.sup.1 and R.sup.2 are hydrogen or C.sub.1 to C.sub.12 linear or branched alkyl; R.sup.3 is hydrogen, C.sub.1 to C.sub.12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R.sup.4 is absent; and when X is nitrogen, R.sup.4 is C.sub.1 to C.sub.12 linear or branched alkyl or nitrogen protecting groups. The compounds are useful as reagents in 1,3-cycloaddition reactions.