Disclosed herein are methods for preparing [(2S,3R)N-[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound G): and precursors thereof. ##STR00001##

Disclosed herein are methods for preparing [(2S,3R)N-[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound G): and precursors thereof. ##STR00001##

The present invention relates to an improved process for the manufacture of 2,6-dimethyl-5-hepten-1-al.

The present invention relates to an improved process for the manufacture of 2,6-dimethyl-5-hepten-1-al.

A compound represented by formula (II): ##STR00001## (where Ar represents a phenyl group optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom and a trifluoromethyl group, and R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms) is produced by step A: reacting trimethyl oxosulfonium salt or trimethyl sulfonium salt with a base in a solvent, and removing the resulting solid to obtain a trimethyl oxosulfonium ylide solution or a trimethyl sulfonium ylide solution; and step B: reacting a compound represented by formula (I): ##STR00002## and the solution obtained in step A, and the compound represented by formula (II) can be derived to a compound represented by formula (V): ##STR00003## that is useful for production of an antifungal agent.

A compound represented by formula (II):

##STR00001##

(where Ar represents a phenyl group optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom and a trifluoromethyl group, and R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms)
is produced by
step A: reacting trimethyl oxosulfonium salt or trimethyl sulfonium salt with a base in a solvent, and removing the resulting solid to obtain a trimethyl oxosulfonium ylide solution or a trimethyl sulfonium ylide solution; and
step B: reacting a compound represented by formula (I):

##STR00002##

and the solution obtained in step A,
and the compound represented by formula (II) can be derived to a compound represented by formula (V):

##STR00003##

that is useful for production of an antifungal agent.

The present invention relates to a process for the preparation of the compounds II

##STR00001##

from the respective oxo compounds. Furthermore, the invention relates to a process for the preparation of triazole compounds from oxiranes II.

The present invention relates to a process for the preparation of the compounds II

##STR00001##

from the respective oxo compounds. Furthermore, the invention relates to a process for the preparation of triazole compounds from oxiranes II.

In one aspect, the present invention encompasses compositions of sustainable polycarbonate polymers, methods of producing such polymers, and methods for evaluating whether certain constituents of a polymer chain are derived from biomass or a fossil carbon source.

Methods of producing glycidyl nitrate. The method comprises reacting glycerol and nitric acid in a microfluidic reactor to form a nitrated glycerol compound. The microfluidic reactor comprises a reaction volume of the microfluidic reactor of less than about 20 ml and an inner diameter of a reaction channel of the microfluidic reactor of less than or equal to about 1000 m. The nitrated glycerol compound is reacted with a base in the microfluidic reactor to form glycidyl nitrate. Additional methods of producing glycidyl nitrate are also disclosed.