Patent classifications
C07D301/02
Methods of producing glycidyl nitrate
Methods of producing glycidyl nitrate. The method comprises reacting glycerol and nitric acid in a microfluidic reactor to form a nitrated glycerol compound. The microfluidic reactor comprises a reaction volume of the microfluidic reactor of less than about 20 ml and an inner diameter of a reaction channel of the microfluidic reactor of less than or equal to about 1000 m. The nitrated glycerol compound is reacted with a base in the microfluidic reactor to form glycidyl nitrate. Additional methods of producing glycidyl nitrate are also disclosed.
SIMPLE OXIDATIVE FUNCTIONALIZED OF ALKYL ARYL KETONES
The present invention refers to a process for reacting an alkyl aryl ketone obtaining thereby the corresponding aryl oxirane or -functionalized alkyl aryl ketal, the aryl oxirane or -functionalized alkyl aryl ketal obtained by the process as well as the -functionalized ketone obtained by the process.
SIMPLE OXIDATIVE FUNCTIONALIZED OF ALKYL ARYL KETONES
The present invention refers to a process for reacting an alkyl aryl ketone obtaining thereby the corresponding aryl oxirane or -functionalized alkyl aryl ketal, the aryl oxirane or -functionalized alkyl aryl ketal obtained by the process as well as the -functionalized ketone obtained by the process.
PREPARATION METHOD FOR EPOXY COMPOUND HAVING ALKOXYSILYL GROUP
Provided is a method for preparing an epoxy compound having an alkoxysilyl group effectively by using a mild catalyst as well as an aromatic alcohol ring-opening agent. The preparation method for an epoxy compound having an alkoxysilyl group includes: performing a ring opening step by reacting an epoxy compound having an epoxide group, which is a starting material, with an aromatic alcohol ring-opening agent in the presence of a phosphine-based catalyst and an optional solvent so as to obtain an intermediate having a partially ring-opened epoxide group; and performing an alkoxysilylation step by reacting the intermediate having a partially ring-opened epoxide with isocyanate alkoxysilane.
PREPARATION METHOD FOR EPOXY COMPOUND HAVING ALKOXYSILYL GROUP
Provided is a method for preparing an epoxy compound having an alkoxysilyl group effectively by using a mild catalyst as well as an aromatic alcohol ring-opening agent. The preparation method for an epoxy compound having an alkoxysilyl group includes: performing a ring opening step by reacting an epoxy compound having an epoxide group, which is a starting material, with an aromatic alcohol ring-opening agent in the presence of a phosphine-based catalyst and an optional solvent so as to obtain an intermediate having a partially ring-opened epoxide group; and performing an alkoxysilylation step by reacting the intermediate having a partially ring-opened epoxide with isocyanate alkoxysilane.
PROCESS FOR THE MANUFACTURE OF 2,6-DIMETHYL-5-HEPTEN-1-AL
The present invention relates to an improved process for the manufacture of 2,6-dimethyl-5-hepten-1-al.
Process of preparing a peptide epoxyketone immunoproteasome inhibitor, and precursors thereof
Disclosed herein are methods for preparing [(2S,3R)N[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound G): ##STR00001##
and precursors thereof.
Process of preparing a peptide epoxyketone immunoproteasome inhibitor, and precursors thereof
Disclosed herein are methods for preparing [(2S,3R)N[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound G): ##STR00001##
and precursors thereof.
ENHANCED PEROXYGEN STABILITY IN MULTI-DISPENSE TAED-CONTAINING PEROXYGEN SOLID
Stabilized compositions employing a sequestrant system and a binding system for improving shelf stability and dispensing stability of a solid activated bleach composition are disclosed. The compositions contain a peroxygen source and a catalyst activator which require generation of a peroxycarboxylic acid or other active oxygen sanitizing agent at a point of use. Stabilized compositions employ a sequestrant system including a phosphonic acid and/or dipicolinic acid sequestrant and a binding system comprising an anionic surfactant for a solid formulation of a catalyst activator and peroxygen source to provide shelf stability and dispensing stability for a activated bleach composition. Methods of formulating and use are further disclosed.
ENHANCED PEROXYGEN STABILITY IN MULTI-DISPENSE TAED-CONTAINING PEROXYGEN SOLID
Stabilized compositions employing a sequestrant system and a binding system for improving shelf stability and dispensing stability of a solid activated bleach composition are disclosed. The compositions contain a peroxygen source and a catalyst activator which require generation of a peroxycarboxylic acid or other active oxygen sanitizing agent at a point of use. Stabilized compositions employ a sequestrant system including a phosphonic acid and/or dipicolinic acid sequestrant and a binding system comprising an anionic surfactant for a solid formulation of a catalyst activator and peroxygen source to provide shelf stability and dispensing stability for a activated bleach composition. Methods of formulating and use are further disclosed.