An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. ##STR00001##
wherein the symbols in the formula are defined below:
R.sup.1: e.g., a C1-C6 alkyl group; R.sup.2: a C1-C6 alkyl group;
A: e.g., an oxygen atom; and R.sup.3: e.g., a C1-C6 alkyl group.

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. ##STR00001##
wherein the symbols in the formula are defined below:
R.sup.1: e.g., a C1-C6 alkyl group; R.sup.2: a C1-C6 alkyl group;
A: e.g., an oxygen atom; and R.sup.3: e.g., a C1-C6 alkyl group.

The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain. Modulators for use in the prophylaxis or treatment of pain include compounds of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof:

##STR00001##

The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain. Modulators for use in the prophylaxis or treatment of pain include compounds of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof:

##STR00001##

Embodiments of the present application relate to an agarofuran compound, a preparation method therefor, and an application thereof. In the embodiments of the present application, structural modification is performed on main metabolic sites, such as alkyl side chain, of 4-butyl-α-agarofuran (BAF) to provide a novel agarofuran compound having higher activity, a better therapeutic effect, and better drug metabolism properties to treat mental illnesses such as anxiety disorders.

Embodiments of the present application relate to an agarofuran compound, a preparation method therefor, and an application thereof. In the embodiments of the present application, structural modification is performed on main metabolic sites, such as alkyl side chain, of 4-butyl-α-agarofuran (BAF) to provide a novel agarofuran compound having higher activity, a better therapeutic effect, and better drug metabolism properties to treat mental illnesses such as anxiety disorders.

The present invention generally relates to compounds, composition matters, and methods for the treatment of a patient with an infection caused by microorganisms, including bacterial, viral, and fungal infections. In particular, this disclosure relates to safe, highly potent and fast acting antimicrobial agents α-methylene and α-aminomethyl lactones, lactams, iminolactones, and iminolactams, thiolactones, thionolactones, thiolactams, and thionolactams having a formula of I, II, III, or IV, for the treatment of viral and bacterial infections, especially for infections caused by methicillin-resistant Staphylococcus aureus (MRSA).

The present invention generally relates to compounds, composition matters, and methods for the treatment of a patient with an infection caused by microorganisms, including bacterial, viral, and fungal infections. In particular, this disclosure relates to safe, highly potent and fast acting antimicrobial agents α-methylene and α-aminomethyl lactones, lactams, iminolactones, and iminolactams, thiolactones, thionolactones, thiolactams, and thionolactams having a formula of I, II, III, or IV, for the treatment of viral and bacterial infections, especially for infections caused by methicillin-resistant Staphylococcus aureus (MRSA).

The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:

##STR00001##

The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:

##STR00001##