The present invention relates to new compounds of formula (I): ##STR00001##
showing great affinity and activity towards the subunit 2 of voltage-gated calcium channels (VGCC), especially the 2-1 subunit of voltage-gated calcium channels or dual activity towards subunit 2 of voltage-gated calcium channels (VGCC), especially the 2-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET).

The present invention provides an aromatic amine compound as represented by formula (1) for improving the light extraction efficiency and color purity of an organic light-emitting element, an organic light-emitting element material containing the aromatic amine compound, a covering layer material of organic light-emitting element, and an organic light-emitting element.

##STR00001##

The organic light-emitting element provided by the present invention can achieve high luminous efficiency and color reproducibility. The organic light-emitting element of the present invention can be used for an organic EL display, a backlight source of a liquid crystal display, illumination, light sources for gauges, a sign board, a marker light, etc. The present invention provides an organic light-emitting element having greatly improved light extraction efficiency and excellent color purity.

The present invention provides an aromatic amine compound as represented by formula (1) for improving the light extraction efficiency and color purity of an organic light-emitting element, an organic light-emitting element material containing the aromatic amine compound, a covering layer material of organic light-emitting element, and an organic light-emitting element.

##STR00001##

The organic light-emitting element provided by the present invention can achieve high luminous efficiency and color reproducibility. The organic light-emitting element of the present invention can be used for an organic EL display, a backlight source of a liquid crystal display, illumination, light sources for gauges, a sign board, a marker light, etc. The present invention provides an organic light-emitting element having greatly improved light extraction efficiency and excellent color purity.

A composition including a first compound represented by a combination of Chemical Formula 1 and Chemical Formula 2, and a second compound represented by Chemical Formula 3, an organic optoelectronic device, and a display device are related.

In Chemical Formula 1 to Chemical Formula 3, each substituent is the same as described in the specification.

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.