The invention provides novel morpholinylpyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory diseases, autoimmune diseases, neurodegenerative disorders, cardiovascular disorders and viral infections;

##STR00001##

wherein R.sup.1, R.sup.2 and A are as defined in the specification.

The invention provides novel morpholinylpyridone compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, type II diabetes, inflammatory diseases, autoimmune diseases, neurodegenerative disorders, cardiovascular disorders and viral infections;

##STR00001##

wherein R.sup.1, R.sup.2 and A are as defined in the specification.

The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S.sub.1P.sub.1 receptor and methods of using the same.

The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S.sub.1P.sub.1 receptor and methods of using the same.

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

The present disclosure relates to azabicyclyl-substituted heterocyclic compounds of formula (I), wherein A.sup.1, A.sup.2, m, R.sup.3, R.sup.4, R.sup.5, L, R.sup.6, T, the ring Y, p, R.sup.7 and Q have the meanings as defined in the specification, to compositions comprising such compounds, to processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.

##STR00001##

The present disclosure relates to azabicyclyl-substituted heterocyclic compounds of formula (I), wherein A.sup.1, A.sup.2, m, R.sup.3, R.sup.4, R.sup.5, L, R.sup.6, T, the ring Y, p, R.sup.7 and Q have the meanings as defined in the specification, to compositions comprising such compounds, to processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.

##STR00001##

The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.