Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.

Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.

The disclosure herein provides compounds and pharmaceutical compositions of the structure of Formula I:

##STR00001##

for the modulation of IL-17A, useful for the treatment of inflammatory conditions, such as psoriasis.

The disclosure herein provides compounds and pharmaceutical compositions of the structure of Formula I:

##STR00001##

for the modulation of IL-17A, useful for the treatment of inflammatory conditions, such as psoriasis.

Disclosed is a composition for inhibiting the growth of virus. More particularly, the composition for inhibiting the growth of virus includes MDPX-V2021 represented by Formula 1, wherein MDPX-V2021 serves to inhibit a post-translational modification (PTM) stage in cells after SARS-CoV-2 penetrates into the body.

Disclosed is a composition for inhibiting the growth of virus. More particularly, the composition for inhibiting the growth of virus includes MDPX-V2021 represented by Formula 1, wherein MDPX-V2021 serves to inhibit a post-translational modification (PTM) stage in cells after SARS-CoV-2 penetrates into the body.

The disclosure herein provides compounds and pharmaceutical compositions for the modulation of IL-17A useful for the treatment of inflammatory conditions, such as psoriasis.

The disclosure herein provides compounds and pharmaceutical compositions for the modulation of IL-17A useful for the treatment of inflammatory conditions, such as psoriasis.

Disclosed is a composition for inhibiting the growth of virus. More particularly, the composition for inhibiting the growth of virus includes MDPX-V2021 represented by Formula 1, wherein MDPX-V2021 serves to inhibit a post-translational modification (PTM) stage in cells after SARS-CoV-2 penetrates into the body.

Disclosed is a composition for inhibiting the growth of virus. More particularly, the composition for inhibiting the growth of virus includes MDPX-V2021 represented by Formula 1, wherein MDPX-V2021 serves to inhibit a post-translational modification (PTM) stage in cells after SARS-CoV-2 penetrates into the body.