Patent classifications
C07D471/22
DONOR-ACCEPTOR TYPE THERMALLY ACTIVATED DELAYED FLUORESCENT MATERIALS BASED ON IMIDAZO[1,2-F]PHENANTHRIDINE AND ANALOGUES
Donor-acceptor type thermally activated delayed fluorescent emitters based on imidazo[1,2-F]phenanthridine and analogues for full color displays and lighting applications.
TRICYCLIC COMPOUNDS WITH OMA1/OPA1 MODULATORY PROPERTIES
Tricyclic compounds, and in particular novel dibenzoxazepin derivates are disclosed herein, which were quite surprisingly found as having OMA1 and/or OPA1 modulatory properties. Compounds of present invention may provide useful for the treatment of certain conditions and diseases, which are amenable to OMA1 and/or OPA1-modulatory therapies. Such conditions may include conditions and diseases prevalent in the elderly, including cancer. Pharmaceutical compositions comprising compounds of present invention may be combined with other treatments or further comprise other pharmaceutically active ingredients.
TRICYCLIC COMPOUNDS WITH OMA1/OPA1 MODULATORY PROPERTIES
Tricyclic compounds, and in particular novel dibenzoxazepin derivates are disclosed herein, which were quite surprisingly found as having OMA1 and/or OPA1 modulatory properties. Compounds of present invention may provide useful for the treatment of certain conditions and diseases, which are amenable to OMA1 and/or OPA1-modulatory therapies. Such conditions may include conditions and diseases prevalent in the elderly, including cancer. Pharmaceutical compositions comprising compounds of present invention may be combined with other treatments or further comprise other pharmaceutically active ingredients.
SUBSTITUTED MACROCYCLIC INDOLE DERIVATIVES
- Kai Thede ,
- Anne Mengel ,
- Clara Christ ,
- Joachim Kuhnke ,
- Sarah Anna Liesa Johannes ,
- Philipp Buchgraber ,
- Ulrich Klar ,
- Ulrike Rauh ,
- Stefan Kaulfuss ,
- Amaury Ernesto Fernandez-Montalvan ,
- Nicolas Werbeck ,
- Ursula Moenning ,
- Katrin Nowak-Reppel ,
- Sven Wittrock ,
- David McKinney ,
- Michael H. Serrano-Wu ,
- Chris Lemke ,
- Mark Fitzgerald ,
- Christopher Nasveschuk ,
- Kiel Lazarski ,
- Steven James Ferrara ,
- Laura Furst ,
- Guo Wei ,
- Patrick Ryan McCarren ,
- Rebecca Ann Harvey
The present invention relates to substituted macrocyclic indole derivatives of general formula (I):
##STR00001##
in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
SUBSTITUTED MACROCYCLIC INDOLE DERIVATIVES
- Kai Thede ,
- Anne Mengel ,
- Clara Christ ,
- Joachim Kuhnke ,
- Sarah Anna Liesa Johannes ,
- Philipp Buchgraber ,
- Ulrich Klar ,
- Ulrike Rauh ,
- Stefan Kaulfuss ,
- Amaury Ernesto Fernandez-Montalvan ,
- Nicolas Werbeck ,
- Ursula Moenning ,
- Katrin Nowak-Reppel ,
- Sven Wittrock ,
- David McKinney ,
- Michael H. Serrano-Wu ,
- Chris Lemke ,
- Mark Fitzgerald ,
- Christopher Nasveschuk ,
- Kiel Lazarski ,
- Steven James Ferrara ,
- Laura Furst ,
- Guo Wei ,
- Patrick Ryan McCarren ,
- Rebecca Ann Harvey
The present invention relates to substituted macrocyclic indole derivatives of general formula (I):
##STR00001##
in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
FLUORESCENT MATERIAL AND METHOD OF SYNTHESIZING THEREOF
A fluorescent material and a method of synthesizing thereof are provided. The fluorescent material includes a formula (1) as follows:
##STR00001##
formula (1), and Y is N or B; X.sub.1 and X.sub.2 are the same or different; X.sub.1 and X.sub.2 are selected from C or Si; R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are the same or different; R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are selected from a hydrogen atom, an alkyl group, an aromatic hydrocarbon group, or a heteroaryl group; R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are the same or different; R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are selected from an alkyl group, an aromatic hydrocarbon group, or a heteroaryl group; or R.sub.5 and R.sub.6 form a cyclic group; or R.sub.7 and Rs form a cyclic group.
FLUORESCENT MATERIAL AND METHOD OF SYNTHESIZING THEREOF
A fluorescent material and a method of synthesizing thereof are provided. The fluorescent material includes a formula (1) as follows:
##STR00001##
formula (1), and Y is N or B; X.sub.1 and X.sub.2 are the same or different; X.sub.1 and X.sub.2 are selected from C or Si; R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are the same or different; R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are selected from a hydrogen atom, an alkyl group, an aromatic hydrocarbon group, or a heteroaryl group; R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are the same or different; R.sub.5, R.sub.6, R.sub.7, and R.sub.8 are selected from an alkyl group, an aromatic hydrocarbon group, or a heteroaryl group; or R.sub.5 and R.sub.6 form a cyclic group; or R.sub.7 and Rs form a cyclic group.
Materials for organic electroluminescent devices
The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
Materials for organic electroluminescent devices
The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.
PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND
The present invention provides a novel compound that has anti-RSV activity and that is useful in the prevention or treatment of an infection in which viruses of the subfamily Pneumovirinae, including respiratory syncytial virus (RSV), are involved, or a pharmaceutically acceptable salt thereof. Specifically, the present invention provides a compound represented by formula (I):
##STR00001##
or a pharmaceutically acceptable salt thereof.