C07D487/22

PHOTOSENSITIZING DYE

It is an object of the present invention to provide a compound that has absorption in a near infrared region, has high efficiency of singlet oxygen generation (quantum yield), and also has high tumor toxicity when it is combined with an immunotoxin. According to the present invention, provided is a compound represented by the following formula (1) or a salt thereof:

##STR00001## wherein L.sub.1 and L.sub.2 each independently represent a single bond, —O—, —CO—, an alkylene group containing 1 to 8 carbon atoms, a sugar chain, or a combination thereof; R.sub.1 and R.sub.2 each independently represent an alkyl group containing 1 to 8 carbon atoms, a carboxylic acid group, an amino group, a hydroxyl group, a thiol group, or a biotin residue; R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 each independently represent an alkyl group containing 1 to 8 carbon atoms, a phenyl group, a carboxylic acid group, an amino group, a hydroxyl group, a thiol group, or a biotin residue; and M represents Mg, Zn, Fe, P, Si, Cu, Sn, Al, Ti, Mo, or Ni.

Porphyrin Compounds and Compositions Useful for Treating Cancer

A porphyrin compound of Formula III

##STR00001## and composition made therefrom comprising a therapeutically effective dose of a porphyrin bound via a linker to an anti-cancer agent useful in treating cancer in a patient in need thereof or to treat cancer cells in-vitro. The compounds and compositions may be delivered by a drug delivery device as disclosed here and be part of a kit.

Porphyrin Compounds and Compositions Useful for Treating Cancer

A porphyrin compound of Formula III

##STR00001## and composition made therefrom comprising a therapeutically effective dose of a porphyrin bound via a linker to an anti-cancer agent useful in treating cancer in a patient in need thereof or to treat cancer cells in-vitro. The compounds and compositions may be delivered by a drug delivery device as disclosed here and be part of a kit.

HETEROCYCLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND ELECTRONIC APPARATUS INCLUDING THE ORGANIC LIGHT-EMITTING DEVICE

Provided are a heterocyclic compound represented by Formula 1, an organic light-emitting device including the same, and an electronic apparatus including the organic light-emitting device:

##STR00001## wherein descriptions of Formula 1 are as defined in the present specification.

HETEROCYCLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND ELECTRONIC APPARATUS INCLUDING THE ORGANIC LIGHT-EMITTING DEVICE

Provided are a heterocyclic compound represented by Formula 1, an organic light-emitting device including the same, and an electronic apparatus including the organic light-emitting device:

##STR00001## wherein descriptions of Formula 1 are as defined in the present specification.

FLUORO SUBSTITUTED PORPHYRIN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME
20210361702 · 2021-11-25 ·

Provided herein are fluoro-substituted porphyrin compounds, such as those having a structure represented by Formula (I), wherein R.sup.1 is a C1-C8 alkyl that is substituted with at least 1 fluorine (e.g., a C1-C8 alkyl substituted with 1-17 fluorine atoms); and X is an anion (e.g. a halogen ion (e.g., chloride, etc.), PF.sub.6, tosylate, besylate, and/or mesylate). Also provided herein are methods of making the fluoro-substituted porphyrin compounds, pharmaceutical formulations containing the same, and methods of use thereof.

ARYL TRIAZOLE CAGES
20210363150 · 2021-11-25 ·

The present disclosure concerns synthesis, anion binding features, liquid-liquid extraction of salts, and anti-corrosion character of aryl-triazole bicyclic macrocycles of Formula (I) and related compounds:

##STR00001##

ARYL TRIAZOLE CAGES
20210363150 · 2021-11-25 ·

The present disclosure concerns synthesis, anion binding features, liquid-liquid extraction of salts, and anti-corrosion character of aryl-triazole bicyclic macrocycles of Formula (I) and related compounds:

##STR00001##

COMPOUND, AND ORGANIC ELECTROLUMINESCENCE DEVICE AND ELECTRONIC APPARATUS USING THE SAME

A compound represented by the following formula (1):

##STR00001## wherein in the formula (1), rings X.sub.1 to X.sub.4 independently a substituted or unsubstituted benzene ring, or a substituted or unsubstituted 6-membered aromatic heterocyclic ring having one or two nitrogen atoms, and at least two of the rings X.sub.1 to X.sub.4 are independently fused with one or more selected from the group consisting of a substituted or unsubstituted hydrocarbon ring including 5 to 50 ring carbon atoms, and a substituted or unsubstituted heterocyclic ring including 5 to 50 ring atoms.

COMPOUND, AND ORGANIC ELECTROLUMINESCENCE DEVICE AND ELECTRONIC APPARATUS USING THE SAME

A compound represented by the following formula (1):

##STR00001## wherein in the formula (1), rings X.sub.1 to X.sub.4 independently a substituted or unsubstituted benzene ring, or a substituted or unsubstituted 6-membered aromatic heterocyclic ring having one or two nitrogen atoms, and at least two of the rings X.sub.1 to X.sub.4 are independently fused with one or more selected from the group consisting of a substituted or unsubstituted hydrocarbon ring including 5 to 50 ring carbon atoms, and a substituted or unsubstituted heterocyclic ring including 5 to 50 ring atoms.