The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.

The present disclosure relates generally to compounds, of Formula I:

##STR00001##

Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

The present disclosure relates generally to compounds, of Formula I:

##STR00001##

Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

The present invention relates to macrocyclic compounds, such as macrocyclic sulfonyl ureas. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP.sub.3 inhibition.

##STR00001##

The present invention relates to macrocyclic compounds, such as macrocyclic sulfonyl ureas. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP.sub.3 inhibition.

##STR00001##

A compound of general formula I and pharmaceutical compositions, kits, methods of making, and methods for treating cancer using the same.

##STR00001##

A compound of general formula I and pharmaceutical compositions, kits, methods of making, and methods for treating cancer using the same.

##STR00001##

A compound of general formula I and pharmaceutical compositions, kits, methods of making, and methods for treating cancer using the same. ##STR00001##

A compound of general formula I and pharmaceutical compositions, kits, methods of making, and methods for treating cancer using the same. ##STR00001##

Compounds of Formula (I):

##STR00001##

pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.