The present disclosure relates to functionalized gold carbene naphthoquinone compounds and salts thereof. In some aspects, these compounds can be used to treat cancer including cancers which are resistant to one or more other chemotherapeutic agents such as cisplatin or platinum chemotherapeutic agents. Also provided herein are pharmaceutical compositions comprising the gold carbene naphthoquinone compounds. The present disclosure also provides methods of preparing a cancer vaccine.

The present disclosure relates to functionalized gold carbene naphthoquinone compounds and salts thereof. In some aspects, these compounds can be used to treat cancer including cancers which are resistant to one or more other chemotherapeutic agents such as cisplatin or platinum chemotherapeutic agents. Also provided herein are pharmaceutical compositions comprising the gold carbene naphthoquinone compounds. The present disclosure also provides methods of preparing a cancer vaccine.

An metal organic complex has the following general formula (I): ##STR00001##
Ar.sup.1, selected from at least one of aromatic hydrocarbyl, R.sup.1-substituted aromatic hydrocarbyl, heterocyclic aromatic hydrocarbyl and R.sup.1-substituted heterocyclic aromatic hydrocarbyl; and Ar.sup.2, selected from one of heterocyclic aromatic hydrocarbyl containing N atoms and R.sup.1-substituted heterocyclic aromatic hydrocarbyl containing N atoms; M being a transitional group metal element; L being selected from one of a monodentate neutral ligand, a monodentate anionic ligand, a bidentate neutral ligand and a bidentate anionic ligand; m being any integer ranging from 1 to 3; and n being any integer ranging from 1 to 2.

A series of thermally stable and highly luminescent cyclometalated tetradentate ligand-containing gold(III) compounds was designed and synthesized. The cyclometalated tetradentate ligand-containing gold(III) compounds can be used as light-emitting material for fabrication of light-emitting devices. The cyclometalated tetradentate ligand-containing gold(III) compounds can be deposited as a layer or a component of a layer using a solution-processing technique or a vacuum deposition process. The cyclometalated tetradentate ligand-containing gold(III) compounds are robust and can provide electroluminescence with high efficiency and brightness. More importantly, the vacuum-deposited OLEDs demonstrate long operational stabilities with half-lifetime of over 29,700 hours at 100 cd m.sup.−2.

The present invention relates to a compound of following formula (I), which is a novel prodrug of biguanide derivatives: (I). The present invention also relates to the preparation and methods of using the compound. In particular, the invention relates to prodrugs wherein metformin and phenformin are attached to Au.sup.III cyclometalated backbone to form novel Au.sup.III prodrugs of metformin or phenformin with improved anticancer effects.

The present invention relates to a compound of following formula (I), which is a novel prodrug of biguanide derivatives: (I). The present invention also relates to the preparation and methods of using the compound. In particular, the invention relates to prodrugs wherein metformin and phenformin are attached to Au.sup.III cyclometalated backbone to form novel Au.sup.III prodrugs of metformin or phenformin with improved anticancer effects.

Provided is an L-glucose derivative represented by General Formula (1) below:

##STR00001## wherein X.sup.1 represents a —SAuR.sup.1 group, and X.sup.2, X.sup.3, X.sup.4 and X.sup.5 each independently represent an —OR.sup.2 group, an —NH.sup.2 group, or a fluorine atom; and R.sup.1 represents a ligand and R.sup.2 represents a hydrogen atom or an organic group.

Platinum, palladium, and gold complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having the structure of Formula VIII. ##STR00001##

Platinum, palladium, and gold complexes suitable for use as phosphorescent emitters or as delayed fluorescent and phosphorescent emitters having the structure of Formula VIII. ##STR00001##

An organogold nonlinear optical chromophore includes gold complexed with a fluorophore optionally substituted an organophosphine ligand or an N-heterocyclic carbene ligand.