The application provides a continuous preparation method for benzylzinc halide and a derivative thereof. The continuous preparation method uses a continuous reactor for reaction of direct inserting a zinc atom into a carbon-halogen bond, wherein the continuous reactor comprises a heating section and a cooling section that are connected to each other, the cooling section is located above the heating section, and the cooling section has a product overflow port, the continuous preparation method comprising: respectively continuously feeding a liquid reaction material and a zinc powder to the heating section, the zinc powder being continuously fed into the heating section from an over part of the heating section, the liquid reaction material being fed into the heating section from a lower part of the heating section, subjecting same to a direct the zinc atom insert into carbon-halogen bond reaction to obtain a product system, and allowing the product system to discharge from the continuous reactor via the product overflow port, wherein the liquid reaction materials comprise a halide, and the halide has structural formula I

##STR00001##

An electrochemical device capable of more sufficiently preventing swelling due to generation of a gas such as carbon dioxide and decomposition of a lithium salt while having a simple structure. The electrochemical device includes a non-aqueous electrolytic solution, wherein the non-aqueous electrolytic solution contains a metal-organic framework containing: an azole-based organic molecule optionally having a hydrophobic group, and a metal atom.

An electrochemical device capable of more sufficiently preventing swelling due to generation of a gas such as carbon dioxide and decomposition of a lithium salt while having a simple structure. The electrochemical device includes a non-aqueous electrolytic solution, wherein the non-aqueous electrolytic solution contains a metal-organic framework containing: an azole-based organic molecule optionally having a hydrophobic group, and a metal atom.

Disclosed herein is an invention that refers to hydrochloride metformin complexes with transition metals and group P elements, such as cobalt (II), nickel (II), copper (II), zinc (III), iron (II), bismuth (III) and their preparation method. Additionally, the present invention offers crystalline forms of the metformin-cobalt (II) complex, metformin-nickel complex and metformin-copper complex as well as methods for therapeutic use in patient treatment and their preparation method.

Disclosed herein is an invention that refers to hydrochloride metformin complexes with transition metals and group P elements, such as cobalt (II), nickel (II), copper (II), zinc (III), iron (II), bismuth (III) and their preparation method. Additionally, the present invention offers crystalline forms of the metformin-cobalt (II) complex, metformin-nickel complex and metformin-copper complex as well as methods for therapeutic use in patient treatment and their preparation method.

The invention relates to a method for producing, amongst other things, amino-acid and/or hydroxycarboxylic-acid metal chelates, a solvent-free mixture of at least one metal oxide, metal hydroxide, metal carbonate or oxalate, and the solid organic acid is subjected to intensive mechanical stress. According to the invention, this is done in that the reaction partners are introduced in particle form into a fluid stream of a fluid-bed countercurrent mill operating without grinding elements, wherein mechanical activation of at least one of the reaction partners is effected by collision processes within a reaction chamber formed in a region of the fluid stream, and a solid body reaction to form the metal chelate is triggered. The novel method operates very energy-efficiently and with a high specific yield. It leads to a product having compact particles in the small, single-digit micrometer range having a comparatively narrow particle sizc distribution and a large surface. The product is homogenous and very pure. Thermal loading or decomposition of the organic chelate ligands, in particular of the amino acids, is likewise avoided, as are contaminants from milling and grinding element abrasion.

The invention relates to a method for producing, amongst other things, amino-acid and/or hydroxycarboxylic-acid metal chelates, a solvent-free mixture of at least one metal oxide, metal hydroxide, metal carbonate or oxalate, and the solid organic acid is subjected to intensive mechanical stress. According to the invention, this is done in that the reaction partners are introduced in particle form into a fluid stream of a fluid-bed countercurrent mill operating without grinding elements, wherein mechanical activation of at least one of the reaction partners is effected by collision processes within a reaction chamber formed in a region of the fluid stream, and a solid body reaction to form the metal chelate is triggered. The novel method operates very energy-efficiently and with a high specific yield. It leads to a product having compact particles in the small, single-digit micrometer range having a comparatively narrow particle sizc distribution and a large surface. The product is homogenous and very pure. Thermal loading or decomposition of the organic chelate ligands, in particular of the amino acids, is likewise avoided, as are contaminants from milling and grinding element abrasion.

Provided is a zinc compound represented by the following general formula (1) or (2):

##STR00001##

in the formula (1), R.sup.1 represents an unsubstituted alkyl group having 1 to 5 carbon atoms, etc., R.sup.2 and R.sup.5 each independently represent a hydrogen atom, a fluorine atom, an unsubstituted alkyl group having 1 to 5 carbon atoms, etc., and R.sup.3 and R.sup.4 each independently represent a hydrogen atom, a fluorine atom, an unsubstituted alkyl group having 1 to 5 carbon atoms, etc.;

##STR00002##

in the formula (2), R.sup.10, R.sup.11, R.sup.14, and R.sup.15 each independently represent a hydrogen atom, a fluorine atom, an unsubstituted alkyl group having 1 to 5 carbon atoms, etc., and R.sup.9, R.sup.12, R.sup.13, and R.sup.16 each independently represent a hydrogen atom, a fluorine atom, an unsubstituted alkyl group having 1 to 5 carbon atoms, etc.

Provided is a zinc compound represented by the following general formula (1) or (2):

##STR00001##

in the formula (1), R.sup.1 represents an unsubstituted alkyl group having 1 to 5 carbon atoms, etc., R.sup.2 and R.sup.5 each independently represent a hydrogen atom, a fluorine atom, an unsubstituted alkyl group having 1 to 5 carbon atoms, etc., and R.sup.3 and R.sup.4 each independently represent a hydrogen atom, a fluorine atom, an unsubstituted alkyl group having 1 to 5 carbon atoms, etc.;

##STR00002##

in the formula (2), R.sup.10, R.sup.11, R.sup.14, and R.sup.15 each independently represent a hydrogen atom, a fluorine atom, an unsubstituted alkyl group having 1 to 5 carbon atoms, etc., and R.sup.9, R.sup.12, R.sup.13, and R.sup.16 each independently represent a hydrogen atom, a fluorine atom, an unsubstituted alkyl group having 1 to 5 carbon atoms, etc.

The present disclosure provides compounds of the formula: ##STR00001##
wherein the variables are defined herein. The present disclosure also provides methods of imaging Zn.sup.2+ within granules in cells, such as pancreatic α-, β-, and δ-cells. The present disclosure also provides methods of sorting cells comprising the use of the compounds of the present disclosure.