Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer are disclosed.

Described are lanthanide-containing metal coordination complexes which may be used as precursors in thin film depositions, e.g. atomic layer deposition processes. More specifically, described are homoleptic lanthanide-aminoalkoxide metal coordination complexes, lanthanide-carbohydrazide metal coordination complexes, and lanthanide-diazadiene metal coordination complexes. Additionally, methods for depositing lanthanide-containing films through an atomic layer deposition process are described.

Provided herein are compounds useful as imaging agents. Exemplary compounds provided herein are useful as myeloperoxidase imaging agents using magnetic resonance or nuclear imaging techniques. Methods for preparing the compounds provided herein and diagnostic methods using the compounds are also provided.

A chelate and associated security feature including a lanthanide metal and a ligand of formula (1), formula (2), or formula (3), ##STR00001##
where each of R.sub.1-R.sub.7 in formula (1) is independently selected from the group consisting of H, OH, NH.sub.2, Cl, F, OMe, OAr, OCF.sub.3, CF.sub.3, alkyl, aryl, phenyl, OPh, and heteroaromatic, where each of R.sub.1-R.sub.5 in formula (2) is independently selected from the group consisting of H, OH, NH.sub.2, Cl, F, OMe, OAr, OCF.sub.3, CF.sub.3, NMe.sub.2, CN, alkyl, aryl, phenyl, OPh, and heteroaromatic, and where R.sub.6 in formula (2) is selected from the group consisting of H, NH.sub.2, Cl, F, OMe, OAr, OCF.sub.3, CF.sub.3, NMe.sub.2, CN, alkyl, aryl, phenyl, OPh, and heteroaromatic, and where each of R.sub.1-R.sub.5 in formula (3) is independently selected from the group consisting of H, OH, NH.sub.2, Cl, F, OMe, OAr, OCF.sub.3, CF.sub.3, alkyl, aryl, phenyl, OPh, and heteroaromatic.

In a compound of the present invention, in a macroscopic view of a chemical structure thereof, a chelating moiety is located at the center of the structure, an atomic group containing an albumin binding moiety binds to one side of the chelating moiety, and an atomic group containing a target molecule binding moiety binds to the other side of the chelating moiety. The chelating moiety is also preferably DOTA or a derivative thereof. The target molecule binding moiety preferably has a structure to bind to a target molecule expressed in a cancer tissue. The present invention also provides a radioactive labeled compound in which the compound is coordinated to a radioactive metal ion.

The present invention relates to novel luminescent lanthanide chelate reporters which are formed from two to three separate lanthanide chelate moieties covalently conjugated to each other to act as an unique labelling reactant, and which can be attached to a biospecific reactant and used in various assays.

The present invention provides an amidinate compound represented by the following general formula (1) or a dimer compound thereof, and a method of producing a thin-film including using the compound as a raw material:

##STR00001##

where R.sup.1 and R.sup.2 each independently represent an alkyl group having 1 to 5 carbon atoms, R.sup.3 represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, M represents a metal atom or a silicon atom, and “n” represents the valence of the atom represented by M, provided that at least one hydrogen atom of R.sup.1 to R.sup.3 is substituted with a fluorine atom.

Provided is a thin-film forming raw material, which is used in an atomic layer deposition method, including a compound represented, by the following formula (1) :

##STR00001##

where R.sup.1 and R.sup.2 each independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, L represents a group represented by the following formula (L-1) or (L-2), and M represents an indium atom or a gallium atom;

##STR00002##

where R.sup.11 and R.sup.12 each independently represent a hydrogen atom, a fluorine atom, an alkyl group having 1 to 5 carbon atoms, or an alkoxy group having 1 to 5 carbon atoms, and * represents a bonding position with M in the formula (1);

##STR00003##

where R.sup.21 to R.sup.23 each independently represent a hydrogen atom, a fluorine atom, or an alkyl group having 1 to 5 carbon atoms, and * represents a bonding position with M in the formula (1), provided that R.sup.21 and R.sup.22 represent different groups.

The present technology relates to luminescent lanthanide complexes comprising a chelating agent, formed of a macrocycle or ligand, complexing a lanthanide ion Ln.sup.3+ selected from terbium and dysprosium, the chelating agent comprising at least one group of the structure (B) below; and a process for detecting a biomolecule using said lanthanide complex comprising coupling a luminescent lanthanide complex of the present technology having a reactive group with said biomolecule. ##STR00001##

The present invention relates to a method of preparing an aqueous dispersion of nanosized cerium (III) carbonate particles comprising the step of admixing in water a) a water-soluble ammonium cerium (III) salt, b) a water-soluble carbonate, and c) a capping ligand to form an aqueous dispersion of cerium (III) carbonate particles having a resultant z-average particle size is in the range of from 5 nm to 500 nm. The method is useful for the preparation of an additive that is useful in formulations that contain polymer, pigments, dyes, or tints, or a combination thereof, to promote color retention and attenuate unwanted color formation in coatings formed from these formulations.